Detailed information of TA system TA206893

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 361393..362053
• Replicon: chromosome
• Accession: NZ_CP077264
• Organism: Enterobacter hormaechei strain FDAARGOS 1434

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: I6L64_RS01625
• Protein ID: WP_047738804.1
• Coordinates: 361393..361746 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: I6L64_RS01630
• Protein ID: WP_000533827.1
• Coordinates: 361751..362053 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L64_RS01615 (I6L64_01615)	360217..360678	+	462	WP_047738808.1	hypothetical protein	-
I6L64_RS01620 (I6L64_01620)	360675..360896	+	222	WP_047738806.1	helix-turn-helix transcriptional regulator	-
I6L64_RS01625 (I6L64_01625)	361393..361746	+	354	WP_047738804.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6L64_RS01630 (I6L64_01630)	361751..362053	+	303	WP_000533827.1	XRE family transcriptional regulator	Antitoxin
I6L64_RS01635 (I6L64_01635)	362562..363449	+	888	WP_069595915.1	integrase domain-containing protein	-
I6L64_RS01640 (I6L64_01640)	364147..365382	-	1236	Protein_324	integrase arm-type DNA-binding domain-containing protein	-
I6L64_RS01650 (I6L64_01650)	365940..366857	+	918	WP_003859531.1	nitrogen assimilation transcriptional regulator NAC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	360675..366857	6182

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13460.27 Da
• Isoelectric Point: 8.9507

>T206893 WP_047738804.1 NZ_CP077264:361393-361746 [Enterobacter hormaechei]
VWTIKTTDTFDRWFASLNDTDRVSVLAALLVLREKGPGLSRPYADTVRGSHYSNMKELRIQSRGDPIRAFFSFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Nucleotide

• Length: 354 bp

>T206893 NZ_CP102748:c1910230-1909973 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11040.81 Da
• Isoelectric Point: 5.7316

>AT206893 WP_000533827.1 NZ_CP077264:361751-362053 [Enterobacter hormaechei]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Nucleotide

• Length: 303 bp

>AT206893 NZ_CP102748:c1910492-1910232 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA