Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3980025..3980587 Replicon chromosome
Accession NZ_CP077242
Organism Escherichia fergusonii strain FDAARGOS 1438

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6L68_RS19030 Protein ID WP_000605678.1
Coordinates 3980025..3980303 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag I6L68_RS19035 Protein ID WP_000781370.1
Coordinates 3980303..3980587 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L68_RS19005 (3975612) 3975612..3976043 - 432 WP_000152299.1 peroxiredoxin OsmC -
I6L68_RS19010 (3976386) 3976386..3976601 + 216 WP_000495766.1 biofilm-dependent modulation protein -
I6L68_RS19015 (3976703) 3976703..3976840 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
I6L68_RS19020 (3976997) 3976997..3978694 + 1698 WP_000433464.1 malate dehydrogenase -
I6L68_RS19025 (3978829) 3978829..3979839 + 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
I6L68_RS19030 (3980025) 3980025..3980303 + 279 WP_000605678.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L68_RS19035 (3980303) 3980303..3980587 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
I6L68_RS19040 (3980638) 3980638..3981291 - 654 WP_000045648.1 formate dehydrogenase-N subunit gamma -
I6L68_RS19045 (3981284) 3981284..3982168 - 885 WP_001240580.1 formate dehydrogenase N subunit beta -
I6L68_RS19050 (3982181) 3982181..3985228 - 3048 WP_015953395.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10478.07 Da        Isoelectric Point: 6.8675

>T206855 WP_000605678.1 NZ_CP077242:3980025-3980303 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWLITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T206855 NZ_CP102719:c1307469-1307212 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT206855 WP_000781370.1 NZ_CP077242:3980303-3980587 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT206855 NZ_CP102719:1307294-1307626 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References