Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1897774..1898031 Replicon chromosome
Accession NZ_CP077242
Organism Escherichia fergusonii strain FDAARGOS 1438

Toxin (Protein)


Gene name hokA Uniprot ID F4T5C6
Locus tag I6L68_RS08990 Protein ID WP_001135731.1
Coordinates 1897879..1898031 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 1897774..1897822 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L68_RS08970 1893005..1894000 - 996 WP_002432855.1 acyltransferase -
I6L68_RS08975 1894172..1894471 + 300 WP_024256552.1 YsaB family lipoprotein -
I6L68_RS08980 1894567..1895478 + 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
I6L68_RS08985 1895488..1897557 + 2070 WP_001291786.1 glycine--tRNA ligase subunit beta -
- 1897774..1897822 - 49 - - Antitoxin
I6L68_RS08990 1897879..1898031 + 153 WP_001135731.1 type I toxin-antitoxin system toxin HokA Toxin
I6L68_RS08995 1898008..1898079 - 72 WP_216665726.1 hypothetical protein -
I6L68_RS09000 1898189..1898560 + 372 WP_001037803.1 membrane protein insertion efficiency factor YidD -
I6L68_RS09005 1898614..1898826 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
I6L68_RS09010 1899108..1899398 - 291 WP_000455800.1 HTH-type transcriptional regulator -
I6L68_RS09015 1899648..1901018 - 1371 WP_000184983.1 MFS transporter -
I6L68_RS09020 1901456..1902166 + 711 WP_000190514.1 DUF3053 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 6025.30 Da        Isoelectric Point: 7.7169

>T206849 WP_001135731.1 NZ_CP077242:1897879-1898031 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Download         Length: 153 bp

>T206849 NZ_CP102716:2436135-2436320 [Lacticaseibacillus rhamnosus]
TTGCAGCGTCAAGGTCATGTAAAATTAGCTTCTCTACATGACCATGCTTTAAAGGGTGCTCACAGCGGCGAACGAGCATT
GCGTGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTAATGCTTCTTGCAACAGGCACAC
ACCGCGATACATTGAACATTGAGTAA

Antitoxin


Download         Length: 49 bp

>AT206849 NZ_CP077242:c1897822-1897774 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061YDD9

Antitoxin

Download structure file

References