Detailed information of TA system TA206847

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 965196..965454
• Replicon: chromosome
• Accession: NZ_CP077242
• Organism: Escherichia fergusonii strain FDAARGOS 1438

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: I6L68_RS04470
• Protein ID: WP_000809173.1
• Coordinates: 965302..965454 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	965196..965253 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L68_RS04445	960999..961940	-	942	WP_000767348.1	bifunctional riboflavin kinase/FAD synthetase	-
I6L68_RS04450	961948..962166	-	219	WP_012599853.1	DUF2575 family protein	-
I6L68_RS04455	962269..962532	+	264	WP_001274021.1	30S ribosomal protein S20	-
I6L68_RS04460	962628..963527	-	900	WP_000019050.1	transcriptional activator NhaR	-
I6L68_RS04465	963595..964761	-	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
-	965196..965253	-	58	-	-	Antitoxin
I6L68_RS04470	965302..965454	+	153	WP_000809173.1	type I toxin-antitoxin system toxin MokC	Toxin
I6L68_RS04475	965559..966689	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
I6L68_RS04480	966778..968694	-	1917	WP_000516135.1	molecular chaperone DnaK	-
I6L68_RS04485	969202..969768	+	567	WP_000528529.1	acetate uptake transporter	-
I6L68_RS04490	969802..970389	-	588	WP_002431696.1	molybdopterin adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5487.54 Da
• Isoelectric Point: 7.1312

>T206847 WP_000809173.1 NZ_CP077242:965302-965454 [Escherichia fergusonii]
MKQHKAMIVALIVICVTAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T206847 NZ_CP102716:390037-390420 [Lacticaseibacillus rhamnosus]
ATGGATGTAACAGTCAAACGCGGGGATGTATTTTTCGCCGATTTATCGCCGGTTGTCGGGTCGGAACAAGGCGGCAACCG
GCCCGTACTTATTATTCAAAACAATGTTGGTAACCATTATAGCCCCACTGTTATCGTGGCTGCCATTACCTCCAAAATCC
AAAAACCCAAAATGCCCACCCATGTCGGTTTGCGCGCCAAGCAAGACGGGGTTGAGCGTAATTCAGTCATTTTGCTTGAA
CAGATTCGTACAATTGATAAGCAACGGTTACAGGCACGCGTTACCGCTCTTTCAAGTGCCAAAATGGCAGCGGTGGATCG
GGCACTGGCGATATCGGTCGGACTCGTCAGCTTGCCTAAGCCGAAAACATATAATAAAAACTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT206847 NZ_CP077242:c965253-965196 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin