Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 659827..660073 Replicon chromosome
Accession NZ_CP077242
Organism Escherichia fergusonii strain FDAARGOS 1438

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag I6L68_RS03080 Protein ID WP_000956458.1
Coordinates 659827..659979 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 660021..660073 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L68_RS03070 655274..656836 - 1563 WP_001084117.1 type I-E CRISPR-associated protein Cse1/CasA -
I6L68_RS03075 656934..659634 - 2701 Protein_598 CRISPR-associated helicase Cas3' -
I6L68_RS03080 659827..659979 - 153 WP_000956458.1 Hok/Gef family protein Toxin
- 660021..660073 + 53 - - Antitoxin
I6L68_RS03085 660246..660980 - 735 WP_148049224.1 phosphoadenosine phosphosulfate reductase -
I6L68_RS03090 661054..662766 - 1713 WP_001003078.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
I6L68_RS03095 662766..664565 - 1800 WP_000211923.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T206843 WP_000956458.1 NZ_CP077242:c659979-659827 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T206843 NZ_CP102698:c33527-33375 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 53 bp

>AT206843 NZ_CP077242:660021-660073 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References