206840

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 17110..17761 Replicon plasmid unnamed1
Accession NZ_CP077239
Organism Acinetobacter pittii strain FDAARGOS 1399

Toxin (Protein)


Gene name higB Uniprot ID A0A7H2WXC0
Locus tag I6L29_RS18370 Protein ID WP_006581604.1
Coordinates 17110..17466 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L29_RS18375 Protein ID WP_001140619.1
Coordinates 17459..17761 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L29_RS18355 (I6L29_18360) 12520..14628 + 2109 WP_002124575.1 TonB-dependent siderophore receptor -
I6L29_RS18360 (I6L29_18365) 14892..15842 + 951 WP_006582413.1 IS481 family transposase -
I6L29_RS18365 (I6L29_18370) 16081..16509 - 429 WP_000877730.1 hypothetical protein -
I6L29_RS18370 (I6L29_18375) 17110..17466 + 357 WP_006581604.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L29_RS18375 (I6L29_18380) 17459..17761 + 303 WP_001140619.1 XRE family transcriptional regulator Antitoxin
I6L29_RS18380 (I6L29_18385) 17754..17963 + 210 WP_000069471.1 hypothetical protein -
I6L29_RS18385 (I6L29_18390) 18073..18291 - 219 WP_029747731.1 hypothetical protein -
I6L29_RS18395 (I6L29_18400) 20288..20833 - 546 Protein_22 IS5-like element ISAba13 family transposase -
I6L29_RS18400 (I6L29_18405) 20761..20967 - 207 WP_233728806.1 AAA family ATPase -
I6L29_RS19170 21021..21149 - 129 WP_002123981.1 AAA family ATPase -
I6L29_RS18405 (I6L29_18410) 21335..21655 + 321 WP_002123990.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
I6L29_RS18410 (I6L29_18415) 21953..22120 + 168 WP_002072926.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6L29_RS18415 (I6L29_18420) 22107..22396 + 290 Protein_27 helix-turn-helix domain-containing protein -
I6L29_RS18420 (I6L29_18425) 22475..22729 - 255 WP_000236586.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..108027 108027
- inside IScluster/Tn - - 14892..20713 5821


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13462.38 Da        Isoelectric Point: 7.1642

>T206840 WP_006581604.1 NZ_CP077239:17110-17466 [Acinetobacter pittii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKDLRVQHRGKSLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Download         Length: 357 bp

>T206840 NZ_CP102697:c4320-4171 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11206.01 Da        Isoelectric Point: 6.7282

>AT206840 WP_001140619.1 NZ_CP077239:17459-17761 [Acinetobacter pittii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT206840 NZ_CP102697:4364-4425 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H2WXC0

Antitoxin

Source ID Structure

References