Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 21750..22191 Replicon plasmid unnamed1
Accession NZ_CP077233
Organism Acinetobacter pittii strain FDAARGOS 1397

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6L27_RS19405 Protein ID WP_002072926.1
Coordinates 21750..21917 (+) Length 56 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6L27_RS19410 Protein ID WP_001258992.1
Coordinates 21904..22191 (+) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L27_RS19365 (I6L27_19365) 16889..17425 - 537 WP_009501148.1 porin family protein -
I6L27_RS19370 (I6L27_19370) 18135..18491 + 357 WP_000269903.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6L27_RS19375 (I6L27_19375) 18484..18786 + 303 WP_001140619.1 XRE family transcriptional regulator -
I6L27_RS19380 (I6L27_19380) 18779..18988 + 210 WP_000069471.1 hypothetical protein -
I6L27_RS19385 (I6L27_19385) 19098..19325 - 228 WP_005071544.1 hypothetical protein -
I6L27_RS19390 (I6L27_19390) 20085..20630 - 546 Protein_29 IS5 family transposase -
I6L27_RS19395 (I6L27_19395) 20558..20764 - 207 WP_242439879.1 AAA family ATPase -
I6L27_RS19400 (I6L27_19400) 21132..21452 + 321 WP_002123990.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
I6L27_RS19405 (I6L27_19405) 21750..21917 + 168 WP_002072926.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L27_RS19410 (I6L27_19410) 21904..22191 + 288 WP_001258992.1 helix-turn-helix transcriptional regulator Antitoxin
I6L27_RS19415 (I6L27_19415) 22475..22699 - 225 WP_016653391.1 hypothetical protein -
I6L27_RS19420 (I6L27_19420) 22723..23280 - 558 Protein_35 hypothetical protein -
I6L27_RS19425 (I6L27_19425) 23320..24636 - 1317 WP_086376539.1 terminase -
I6L27_RS19430 (I6L27_19430) 24620..25161 - 542 Protein_37 DUF2280 domain-containing protein -
I6L27_RS19435 (I6L27_19435) 25221..25862 - 642 WP_005071561.1 putative metallopeptidase -
I6L27_RS19440 (I6L27_19440) 25831..26298 - 468 WP_005071563.1 hypothetical protein -
I6L27_RS19445 (I6L27_19445) 26359..26814 - 456 WP_005071565.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..69574 69574
- flank IS/Tn - - 20085..20330 245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-48)

Antitoxin

(39-90)


Sequences


Toxin        


Download         Length: 56 a.a.        Molecular weight: 6362.64 Da        Isoelectric Point: 11.0180

>T206821 WP_002072926.1 NZ_CP077233:21750-21917 [Acinetobacter pittii]
MRLKSQEGIARVMYCTLVGKRIVMLHSFVKKTQKTPKQDLNLALDRMKEVKNANT

Download         Length: 168 bp

>T206821 NZ_CP102693:11172-11588 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10563.32 Da        Isoelectric Point: 9.7308

>AT206821 WP_001258992.1 NZ_CP077233:21904-22191 [Acinetobacter pittii]
MRTHEEMKALALSRSAVRTEYERIEREEMPLLDMVLTALREAGLSQAQIAERMGTNVPAVSRLEKALITGKPSPSIATLQ
KYAAAIGKHVEVRFV

Download         Length: 288 bp

>AT206821 NZ_CP102693:10945-11175 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References