Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
Location | 21750..22191 | Replicon | plasmid unnamed1 |
Accession | NZ_CP077233 | ||
Organism | Acinetobacter pittii strain FDAARGOS 1397 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | I6L27_RS19405 | Protein ID | WP_002072926.1 |
Coordinates | 21750..21917 (+) | Length | 56 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | I6L27_RS19410 | Protein ID | WP_001258992.1 |
Coordinates | 21904..22191 (+) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6L27_RS19365 (I6L27_19365) | 16889..17425 | - | 537 | WP_009501148.1 | porin family protein | - |
I6L27_RS19370 (I6L27_19370) | 18135..18491 | + | 357 | WP_000269903.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
I6L27_RS19375 (I6L27_19375) | 18484..18786 | + | 303 | WP_001140619.1 | XRE family transcriptional regulator | - |
I6L27_RS19380 (I6L27_19380) | 18779..18988 | + | 210 | WP_000069471.1 | hypothetical protein | - |
I6L27_RS19385 (I6L27_19385) | 19098..19325 | - | 228 | WP_005071544.1 | hypothetical protein | - |
I6L27_RS19390 (I6L27_19390) | 20085..20630 | - | 546 | Protein_29 | IS5 family transposase | - |
I6L27_RS19395 (I6L27_19395) | 20558..20764 | - | 207 | WP_242439879.1 | AAA family ATPase | - |
I6L27_RS19400 (I6L27_19400) | 21132..21452 | + | 321 | WP_002123990.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
I6L27_RS19405 (I6L27_19405) | 21750..21917 | + | 168 | WP_002072926.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
I6L27_RS19410 (I6L27_19410) | 21904..22191 | + | 288 | WP_001258992.1 | helix-turn-helix transcriptional regulator | Antitoxin |
I6L27_RS19415 (I6L27_19415) | 22475..22699 | - | 225 | WP_016653391.1 | hypothetical protein | - |
I6L27_RS19420 (I6L27_19420) | 22723..23280 | - | 558 | Protein_35 | hypothetical protein | - |
I6L27_RS19425 (I6L27_19425) | 23320..24636 | - | 1317 | WP_086376539.1 | terminase | - |
I6L27_RS19430 (I6L27_19430) | 24620..25161 | - | 542 | Protein_37 | DUF2280 domain-containing protein | - |
I6L27_RS19435 (I6L27_19435) | 25221..25862 | - | 642 | WP_005071561.1 | putative metallopeptidase | - |
I6L27_RS19440 (I6L27_19440) | 25831..26298 | - | 468 | WP_005071563.1 | hypothetical protein | - |
I6L27_RS19445 (I6L27_19445) | 26359..26814 | - | 456 | WP_005071565.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..69574 | 69574 | |
- | flank | IS/Tn | - | - | 20085..20330 | 245 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 56 a.a. Molecular weight: 6362.64 Da Isoelectric Point: 11.0180
>T206821 WP_002072926.1 NZ_CP077233:21750-21917 [Acinetobacter pittii]
MRLKSQEGIARVMYCTLVGKRIVMLHSFVKKTQKTPKQDLNLALDRMKEVKNANT
MRLKSQEGIARVMYCTLVGKRIVMLHSFVKKTQKTPKQDLNLALDRMKEVKNANT
Download Length: 168 bp
>T206821 NZ_CP102693:11172-11588 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10563.32 Da Isoelectric Point: 9.7308
>AT206821 WP_001258992.1 NZ_CP077233:21904-22191 [Acinetobacter pittii]
MRTHEEMKALALSRSAVRTEYERIEREEMPLLDMVLTALREAGLSQAQIAERMGTNVPAVSRLEKALITGKPSPSIATLQ
KYAAAIGKHVEVRFV
MRTHEEMKALALSRSAVRTEYERIEREEMPLLDMVLTALREAGLSQAQIAERMGTNVPAVSRLEKALITGKPSPSIATLQ
KYAAAIGKHVEVRFV
Download Length: 288 bp
>AT206821 NZ_CP102693:10945-11175 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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