Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 18135..18786 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP077233 | ||
| Organism | Acinetobacter pittii strain FDAARGOS 1397 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | S3SZA7 |
| Locus tag | I6L27_RS19370 | Protein ID | WP_000269903.1 |
| Coordinates | 18135..18491 (+) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | I6L27_RS19375 | Protein ID | WP_001140619.1 |
| Coordinates | 18484..18786 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L27_RS19340 (I6L27_19340) | 13370..14365 | + | 996 | WP_086376833.1 | AraC family transcriptional regulator | - |
| I6L27_RS19345 (I6L27_19345) | 14382..14894 | + | 513 | WP_086376834.1 | hypothetical protein | - |
| I6L27_RS19350 (I6L27_19350) | 15049..15561 | + | 513 | WP_001089572.1 | SMI1/KNR4 family protein | - |
| I6L27_RS19355 (I6L27_19355) | 15781..16152 | - | 372 | WP_004796420.1 | RcnB family protein | - |
| I6L27_RS19360 (I6L27_19360) | 16489..16719 | + | 231 | WP_004796422.1 | hypothetical protein | - |
| I6L27_RS19365 (I6L27_19365) | 16889..17425 | - | 537 | WP_009501148.1 | porin family protein | - |
| I6L27_RS19370 (I6L27_19370) | 18135..18491 | + | 357 | WP_000269903.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| I6L27_RS19375 (I6L27_19375) | 18484..18786 | + | 303 | WP_001140619.1 | XRE family transcriptional regulator | Antitoxin |
| I6L27_RS19380 (I6L27_19380) | 18779..18988 | + | 210 | WP_000069471.1 | hypothetical protein | - |
| I6L27_RS19385 (I6L27_19385) | 19098..19325 | - | 228 | WP_005071544.1 | hypothetical protein | - |
| I6L27_RS19390 (I6L27_19390) | 20085..20630 | - | 546 | Protein_29 | IS5 family transposase | - |
| I6L27_RS19395 (I6L27_19395) | 20558..20764 | - | 207 | WP_242439879.1 | AAA family ATPase | - |
| I6L27_RS19400 (I6L27_19400) | 21132..21452 | + | 321 | WP_002123990.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| I6L27_RS19405 (I6L27_19405) | 21750..21917 | + | 168 | WP_002072926.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| I6L27_RS19410 (I6L27_19410) | 21904..22191 | + | 288 | WP_001258992.1 | helix-turn-helix transcriptional regulator | - |
| I6L27_RS19415 (I6L27_19415) | 22475..22699 | - | 225 | WP_016653391.1 | hypothetical protein | - |
| I6L27_RS19420 (I6L27_19420) | 22723..23280 | - | 558 | Protein_35 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..69574 | 69574 | |
| - | flank | IS/Tn | - | - | 20085..20330 | 245 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13486.45 Da Isoelectric Point: 7.1645
>T206820 WP_000269903.1 NZ_CP077233:18135-18491 [Acinetobacter pittii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
Download Length: 357 bp
>T206820 NZ_CP102693:c10137-9832 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGGTCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTCTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGGTCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTCTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11206.01 Da Isoelectric Point: 6.7282
>AT206820 WP_001140619.1 NZ_CP077233:18484-18786 [Acinetobacter pittii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
Download Length: 303 bp
>AT206820 NZ_CP102693:c10357-10139 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCGGACGTCAATATCTCCGGCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCCGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCGGACGTCAATATCTCCGGCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCCGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|