Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 554614..555229 | Replicon | chromosome |
| Accession | NZ_CP077198 | ||
| Organism | Vibrio cholerae strain PS-4 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | KTC41_RS15300 | Protein ID | WP_001162670.1 |
| Coordinates | 554614..554901 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KTC41_RS15305 | Protein ID | WP_001232701.1 |
| Coordinates | 554912..555229 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTC41_RS15260 (KTC41_15270) | 549663..551429 | + | 1767 | WP_220285321.1 | P-loop NTPase fold protein | - |
| KTC41_RS17690 | 551752..551845 | + | 94 | Protein_516 | ggdef family protein | - |
| KTC41_RS17695 | 551814..551945 | + | 132 | WP_001883067.1 | hypothetical protein | - |
| KTC41_RS15275 (KTC41_15285) | 552107..552604 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| KTC41_RS15280 (KTC41_15290) | 552601..552873 | - | 273 | WP_000246255.1 | DUF1778 domain-containing protein | - |
| KTC41_RS15285 (KTC41_15295) | 553114..553584 | + | 471 | WP_220285309.1 | GNAT family N-acetyltransferase | - |
| KTC41_RS15290 (KTC41_15300) | 553720..554037 | - | 318 | WP_220285319.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KTC41_RS15295 (KTC41_15305) | 554056..554298 | - | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| KTC41_RS15300 (KTC41_15310) | 554614..554901 | + | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KTC41_RS15305 (KTC41_15315) | 554912..555229 | + | 318 | WP_001232701.1 | HigA family addiction module antitoxin | Antitoxin |
| KTC41_RS15310 (KTC41_15320) | 555866..556276 | + | 411 | WP_220285322.1 | hypothetical protein | - |
| KTC41_RS17700 | 556381..556524 | + | 144 | WP_080300930.1 | acetyltransferase | - |
| KTC41_RS17705 | 556657..556712 | + | 56 | Protein_527 | DUF645 family protein | - |
| KTC41_RS17710 | 556691..556786 | + | 96 | WP_230965109.1 | Tfp pilus assembly protein | - |
| KTC41_RS17715 | 556883..556997 | + | 115 | Protein_529 | acetyltransferase | - |
| KTC41_RS15320 (KTC41_15330) | 557006..557227 | + | 222 | WP_258873430.1 | DUF1289 domain-containing protein | - |
| KTC41_RS15325 (KTC41_15335) | 557540..557929 | + | 390 | WP_186295662.1 | VOC family protein | - |
| KTC41_RS15330 (KTC41_15340) | 558416..558793 | + | 378 | WP_220285324.1 | hypothetical protein | - |
| KTC41_RS17720 | 558858..558926 | + | 69 | Protein_533 | acetyltransferase | - |
| KTC41_RS15335 (KTC41_15345) | 559094..559276 | + | 183 | WP_033838039.1 | DUF645 family protein | - |
| KTC41_RS15340 (KTC41_15350) | 559480..559701 | + | 222 | WP_088129314.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 505519..626164 | 120645 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T206767 WP_001162670.1 NZ_CP077198:554614-554901 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T206767 NZ_CP102679:c289924-289460 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT206767 WP_001232701.1 NZ_CP077198:554912-555229 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT206767 NZ_CP102679:c290259-289924 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|