Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 518302..518917 | Replicon | chromosome |
| Accession | NZ_CP077198 | ||
| Organism | Vibrio cholerae strain PS-4 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | KTC41_RS14995 | Protein ID | WP_001162670.1 |
| Coordinates | 518302..518589 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KTC41_RS15000 | Protein ID | WP_001232701.1 |
| Coordinates | 518600..518917 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTC41_RS14965 (KTC41_14970) | 513811..514047 | + | 237 | WP_217519997.1 | DUF3709 domain-containing protein | - |
| KTC41_RS14970 (KTC41_14975) | 514315..514719 | + | 405 | WP_220285306.1 | hypothetical protein | - |
| KTC41_RS17600 (KTC41_14980) | 514723..514845 | + | 123 | WP_225450089.1 | DUF3265 domain-containing protein | - |
| KTC41_RS17605 | 514958..515239 | + | 282 | Protein_449 | type VI secretion system PAAR protein | - |
| KTC41_RS14980 (KTC41_14990) | 516070..516510 | + | 441 | WP_220285308.1 | hypothetical protein | - |
| KTC41_RS17610 | 516580..516756 | + | 177 | WP_258873417.1 | acetyltransferase | - |
| KTC41_RS17615 | 516889..516944 | + | 56 | Protein_452 | DUF645 family protein | - |
| KTC41_RS17620 | 516923..517018 | + | 96 | WP_230965109.1 | Tfp pilus assembly protein | - |
| KTC41_RS14990 (KTC41_15000) | 517204..517674 | + | 471 | WP_220285309.1 | GNAT family N-acetyltransferase | - |
| KTC41_RS14995 (KTC41_15005) | 518302..518589 | + | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KTC41_RS15000 (KTC41_15010) | 518600..518917 | + | 318 | WP_001232701.1 | HigA family addiction module antitoxin | Antitoxin |
| KTC41_RS15005 (KTC41_15015) | 519076..519297 | + | 222 | WP_088129314.1 | hypothetical protein | - |
| KTC41_RS15010 (KTC41_15020) | 519539..519847 | + | 309 | WP_001062214.1 | transposase | - |
| KTC41_RS15015 (KTC41_15025) | 519844..520695 | + | 852 | WP_220285310.1 | IS3 family transposase | - |
| KTC41_RS15020 (KTC41_15030) | 520767..520988 | + | 222 | WP_088129314.1 | hypothetical protein | - |
| KTC41_RS15025 (KTC41_15035) | 521335..521517 | + | 183 | WP_001933694.1 | DUF645 family protein | - |
| KTC41_RS15030 (KTC41_15040) | 521719..522165 | + | 447 | WP_258873421.1 | hypothetical protein | - |
| KTC41_RS15035 (KTC41_15045) | 522332..522751 | - | 420 | WP_111673657.1 | BLUF domain-containing protein | - |
| KTC41_RS15040 (KTC41_15050) | 523004..523267 | + | 264 | WP_220285822.1 | hypothetical protein | - |
| KTC41_RS15045 (KTC41_15055) | 523449..523844 | + | 396 | WP_220285311.1 | DUF3465 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 505519..626164 | 120645 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T206761 WP_001162670.1 NZ_CP077198:518302-518589 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T206761 NZ_CP102675:4889019-4889122 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT206761 WP_001232701.1 NZ_CP077198:518600-518917 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT206761 NZ_CP102675:c4889160-4888889 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|