Detailed information of TA system TA206757

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2574666..2575183
• Replicon: chromosome
• Accession: NZ_CP077098
• Organism: Staphylococcus aureus strain RGB-095930

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YC79
• Locus tag: KSF82_RS13115
• Protein ID: WP_000113262.1
• Coordinates: 2574666..2574932 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: KSF82_RS13120
• Protein ID: WP_089535274.1
• Coordinates: 2574932..2575183 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSF82_RS13090 (2569935)	2569935..2570471	-	537	WP_000024292.1	GNAT family N-acetyltransferase	-
KSF82_RS13095 (2570877)	2570877..2571701	-	825	WP_089535273.1	formate/nitrite transporter family protein	-
KSF82_RS13100 (2571904)	2571904..2572086	-	183	WP_000079140.1	hypothetical protein	-
KSF82_RS13105 (2572173)	2572173..2572640	-	468	WP_000153342.1	SRPBCC domain-containing protein	-
KSF82_RS13110 (2572826)	2572826..2574373	-	1548	WP_000727770.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
KSF82_RS14805 (2574560)	2574560..2574631	-	72	WP_234697003.1	hypothetical protein	-
KSF82_RS13115 (2574666)	2574666..2574932	-	267	WP_000113262.1	Txe/YoeB family addiction module toxin	Toxin
KSF82_RS13120 (2574932)	2574932..2575183	-	252	WP_089535274.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KSF82_RS13125 (2575347)	2575347..2575448	-	102	Protein_2563	hypothetical protein	-
KSF82_RS13130 (2575455)	2575455..2576054	-	600	WP_070974178.1	DsbA family protein	-
KSF82_RS13135 (2576073)	2576073..2576435	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
KSF82_RS13140 (2576690)	2576690..2577940	+	1251	WP_089535275.1	FemA/FemB family glycyltransferase FmhA	-
KSF82_RS13145 (2578037)	2578037..2578768	-	732	WP_000615467.1	amino acid ABC transporter ATP-binding protein	-
KSF82_RS13150 (2578765)	2578765..2579484	-	720	WP_000479573.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.95 Da
• Isoelectric Point: 9.9143

>T206757 WP_000113262.1 NZ_CP077098:c2574932-2574666 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T206757 NZ_CP102675:4158499-4158897 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9420.60 Da
• Isoelectric Point: 4.3407

>AT206757 WP_089535274.1 NZ_CP077098:c2575183-2574932 [Staphylococcus aureus]
MIIKTYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT206757 NZ_CP102675:4158272-4158499 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Structures

Toxin

• PDB: 6L8G
• PDB: 6L8F
• PDB: 7CUA
• PDB: 6L8E