Detailed information of TA system TA206750

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2126553..2126860
• Replicon: chromosome
• Accession: NZ_CP077098
• Organism: Staphylococcus aureus strain RGB-095930

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KSF82_RS10670
• Protein ID: WP_011447039.1
• Coordinates: 2126684..2126860 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2126553..2126692 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSF82_RS10625 (2121562)	2121562..2121759	+	198	WP_000239610.1	phospholipase	-
KSF82_RS10630 (2122120)	2122120..2122299	+	180	WP_000669791.1	hypothetical protein	-
KSF82_RS10635 (2122610)	2122610..2122870	+	261	WP_001791826.1	hypothetical protein	-
KSF82_RS10640 (2122923)	2122923..2123273	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KSF82_RS10645 (2123783)	2123783..2124118	-	336	Protein_2078	SH3 domain-containing protein	-
KSF82_RS10650 (2124769)	2124769..2125260	-	492	WP_000920038.1	staphylokinase	-
KSF82_RS10655 (2125451)	2125451..2126206	-	756	WP_000861038.1	CHAP domain-containing protein	-
KSF82_RS10660 (2126218)	2126218..2126472	-	255	WP_000611508.1	phage holin	-
KSF82_RS10665 (2126524)	2126524..2126631	+	108	WP_031762631.1	hypothetical protein	-
- (2126553)	2126553..2126692	+	140	NuclAT_0	-	Antitoxin
- (2126553)	2126553..2126692	+	140	NuclAT_0	-	Antitoxin
- (2126553)	2126553..2126692	+	140	NuclAT_0	-	Antitoxin
- (2126553)	2126553..2126692	+	140	NuclAT_0	-	Antitoxin
KSF82_RS10670 (2126684)	2126684..2126860	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KSF82_RS10675 (2126969)	2126969..2127742	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
KSF82_RS10680 (2128115)	2128115..2128489	-	375	WP_000340977.1	hypothetical protein	-
KSF82_RS10685 (2128545)	2128545..2128832	-	288	WP_001262621.1	hypothetical protein	-
KSF82_RS10690 (2128878)	2128878..2129030	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2122923..2195948	73025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T206750 WP_011447039.1 NZ_CP077098:c2126860-2126684 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T206750 NZ_CP102675:c2590340-2590029 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT206750 NZ_CP077098:2126553-2126692 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin