Detailed information of TA system TA206746

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1922787..1922969
• Replicon: chromosome
• Accession: NZ_CP077098
• Organism: Staphylococcus aureus strain RGB-095930

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KSF82_RS09350
• Protein ID: WP_001801861.1
• Coordinates: 1922787..1922882 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1922910..1922969 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSF82_RS09305	1918040..1918384	+	345	WP_000627551.1	DUF3969 family protein	-
KSF82_RS09310	1918482..1919033	+	552	WP_000414205.1	hypothetical protein	-
KSF82_RS09315	1919251..1919535	-	285	Protein_1848	hypothetical protein	-
KSF82_RS09320	1919546..1920493	-	948	WP_089536049.1	IS30-like element ISSau1 family transposase	-
KSF82_RS09325	1920607..1920966	-	360	Protein_1850	hypothetical protein	-
KSF82_RS09330	1921080..1921265	-	186	WP_000809857.1	hypothetical protein	-
KSF82_RS09335	1921267..1921443	-	177	WP_000375476.1	hypothetical protein	-
KSF82_RS09340	1921454..1921837	-	384	WP_000070811.1	hypothetical protein	-
KSF82_RS09345	1922441..1922584	-	144	WP_001549059.1	transposase	-
KSF82_RS09350	1922787..1922882	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1922910..1922969	-	60	-	-	Antitoxin
KSF82_RS09355	1923005..1923106	+	102	WP_001791893.1	hypothetical protein	-
KSF82_RS09360	1923084..1923260	-	177	Protein_1857	transposase	-
KSF82_RS09365	1923454..1923831	-	378	WP_001037045.1	DUF1433 domain-containing protein	-
KSF82_RS09370	1924352..1927936	-	3585	Protein_1859	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1893540..1977806	84266
	-	flank	IS/Tn	-	-	1919546..1920493	947

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T206746 WP_001801861.1 NZ_CP077098:1922787-1922882 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T206746 NZ_CP102675:c2021180-2020893 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTAAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT206746 NZ_CP077098:c1922969-1922910 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin