Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4260865..4261451 Replicon chromosome
Accession NZ_CP077095
Organism Pseudomonas xantholysinigenes strain RW9S1A

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HU772_RS19020 Protein ID WP_186660036.1
Coordinates 4260865..4261143 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag HU772_RS19025 Protein ID WP_186660034.1
Coordinates 4261152..4261451 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU772_RS19005 (HU772_019005) 4256973..4258166 + 1194 WP_186660041.1 succinyldiaminopimelate transaminase -
HU772_RS19010 (HU772_019010) 4258242..4258988 + 747 WP_186660040.1 M12 family metallopeptidase -
HU772_RS19015 (HU772_019015) 4258981..4260627 - 1647 WP_186660038.1 Na+/H+ antiporter -
HU772_RS19020 (HU772_019020) 4260865..4261143 + 279 WP_186660036.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU772_RS19025 (HU772_019025) 4261152..4261451 + 300 WP_186660034.1 HigA family addiction module antitoxin Antitoxin
HU772_RS19030 (HU772_019030) 4261562..4261909 + 348 WP_186660032.1 ArsC family reductase -
HU772_RS19035 (HU772_019035) 4261951..4262985 + 1035 WP_186660030.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
HU772_RS19040 (HU772_019040) 4263066..4264271 + 1206 WP_186660028.1 cysteine desulfurase -
HU772_RS19045 (HU772_019045) 4264268..4264678 + 411 WP_186660027.1 SufE family protein -
HU772_RS19050 (HU772_019050) 4264771..4265580 - 810 WP_186660026.1 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10578.00 Da        Isoelectric Point: 9.4158

>T206739 WP_186660036.1 NZ_CP077095:4260865-4261143 [Pseudomonas xantholysinigenes]
MIRSFRCAETQTLFTTGKTRRWSQIKSIAERKLAMLDAAKALRDLRSPPGNRLEQLSGDRSGQHSIRINDQCRICFNWSD
EGPANVEIIDYH

Download         Length: 279 bp

>T206739 NZ_CP102675:c381840-381664 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10783.36 Da        Isoelectric Point: 5.6480

>AT206739 WP_186660034.1 NZ_CP077095:4261152-4261451 [Pseudomonas xantholysinigenes]
MLTNGMRPIHPGEVLREDFQKELGLSAAALARALGVATPTVNNILRERGGVSADMALRLSICLDTTPEFWLNLQSAFDLR
TAQQQHGDEIIGSVQRLVA

Download         Length: 300 bp

>AT206739 NZ_CP102675:c381618-381202 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References