Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1155850..1156454 Replicon chromosome
Accession NZ_CP077095
Organism Pseudomonas xantholysinigenes strain RW9S1A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HU772_RS05310 Protein ID WP_186659230.1
Coordinates 1156134..1156454 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HU772_RS05305 Protein ID WP_186659233.1
Coordinates 1155850..1156137 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU772_RS05295 (HU772_005295) 1151852..1154215 + 2364 WP_186659238.1 TonB-dependent receptor -
HU772_RS05300 (HU772_005300) 1154223..1155824 + 1602 WP_186659236.1 alpha/beta hydrolase-fold protein -
HU772_RS05305 (HU772_005305) 1155850..1156137 - 288 WP_186659233.1 NadS family protein Antitoxin
HU772_RS05310 (HU772_005310) 1156134..1156454 - 321 WP_186659230.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU772_RS05315 (HU772_005315) 1156585..1158285 - 1701 WP_186659227.1 SulP family inorganic anion transporter -
HU772_RS05325 (HU772_005325) 1158874..1159758 - 885 WP_186659224.1 alpha/beta hydrolase -
HU772_RS05330 (HU772_005330) 1160121..1160813 - 693 WP_186659221.1 pseudouridine synthase -
HU772_RS05335 (HU772_005335) 1160845..1161066 - 222 WP_186659218.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11998.91 Da        Isoelectric Point: 9.7316

>T206737 WP_186659230.1 NZ_CP077095:c1156454-1156134 [Pseudomonas xantholysinigenes]
MLFTETAIFTKRVQELLDDESYRLLQVRLLMCPDAGDTIEGTGGLRKIRIAAKGHGKRGGARVIYYHFVSASHIAMLYIY
PKNEQPDLNAEQRKALKAVIAHWSQP

Download         Length: 321 bp

>T206737 NZ_CP102674:32947-33327 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTTTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10897.48 Da        Isoelectric Point: 8.9086

>AT206737 WP_186659233.1 NZ_CP077095:c1156137-1155850 [Pseudomonas xantholysinigenes]
MNRLFDELMESVEQMDAIVHGRRQPARQFEIDALQVKNIRKATGLSQTRFAEMIDVQVATLRNWEQGRREPTGPAKALLR
AIHNDPDHVLKALAH

Download         Length: 288 bp

>AT206737 NZ_CP102674:32726-32947 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References