Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 6066424..6067150 | Replicon | chromosome |
Accession | NZ_CP077093 | ||
Organism | Pseudomonas vanderleydeniana strain RW8P3 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | HU752_RS27275 | Protein ID | WP_186678239.1 |
Coordinates | 6066839..6067150 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A9E6PJC5 |
Locus tag | HU752_RS27270 | Protein ID | WP_017902440.1 |
Coordinates | 6066424..6066837 (-) | Length | 138 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HU752_RS27250 (HU752_027250) | 6061948..6063597 | - | 1650 | WP_186678221.1 | alpha,alpha-phosphotrehalase | - |
HU752_RS27255 (HU752_027255) | 6063629..6065071 | - | 1443 | WP_186678235.1 | PTS system trehalose-specific EIIBC component | - |
HU752_RS27260 (HU752_027260) | 6065296..6066000 | + | 705 | WP_186678237.1 | trehalose operon repressor | - |
HU752_RS27265 (HU752_027265) | 6066020..6066310 | - | 291 | WP_225920075.1 | hypothetical protein | - |
HU752_RS27270 (HU752_027270) | 6066424..6066837 | - | 414 | WP_017902440.1 | transcriptional regulator | Antitoxin |
HU752_RS27275 (HU752_027275) | 6066839..6067150 | - | 312 | WP_186678239.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
HU752_RS27280 (HU752_027280) | 6067447..6069024 | - | 1578 | WP_186678241.1 | glutamine-hydrolyzing GMP synthase | - |
HU752_RS27285 (HU752_027285) | 6069130..6070599 | - | 1470 | WP_054057407.1 | IMP dehydrogenase | - |
HU752_RS27290 (HU752_027290) | 6070682..6071230 | - | 549 | WP_186678242.1 | sugar ABC transporter ATPase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12154.85 Da Isoelectric Point: 9.3209
>T206734 WP_186678239.1 NZ_CP077093:c6067150-6066839 [Pseudomonas vanderleydeniana]
MHVISRKPFSDAASAYPNDVEAIDRTYRVLRSGEFDTPQALGKVFPSLDNFKYKDKWWVLDIGGNNLRLIAFIEFRDNRL
YVKHIVTHAEYDKLCKRYRKEAD
MHVISRKPFSDAASAYPNDVEAIDRTYRVLRSGEFDTPQALGKVFPSLDNFKYKDKWWVLDIGGNNLRLIAFIEFRDNRL
YVKHIVTHAEYDKLCKRYRKEAD
Download Length: 312 bp
>T206734 NZ_CP102672:c35288-35034 [Escherichia coli]
ATGAGAAAAAACAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA
ATGAGAAAAAACAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA
Antitoxin
Download Length: 138 a.a. Molecular weight: 15111.29 Da Isoelectric Point: 4.8002
>AT206734 WP_017902440.1 NZ_CP077093:c6066837-6066424 [Pseudomonas vanderleydeniana]
MGFAAIKEKAYALFSEAGFISHIANDDDYAKALALMDDLVEDYEVNRPLIEILARSIESWENESEEFVAFNARVAKLGGV
DVLRLLMEQHGLGVADLPEIGSKSLVSKILNGRGRNLTRDHIAALSKRFAVSPALFF
MGFAAIKEKAYALFSEAGFISHIANDDDYAKALALMDDLVEDYEVNRPLIEILARSIESWENESEEFVAFNARVAKLGGV
DVLRLLMEQHGLGVADLPEIGSKSLVSKILNGRGRNLTRDHIAALSKRFAVSPALFF
Download Length: 414 bp
>AT206734 NZ_CP102672:c35037-34795 [Escherichia coli]
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGAAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGAAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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