Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4331005..4331596 Replicon chromosome
Accession NZ_CP077091
Organism Pseudomonas hamedanensis strain SWRI65

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HU739_RS18755 Protein ID WP_186549755.1
Coordinates 4331005..4331283 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag HU739_RS18760 Protein ID WP_186549696.1
Coordinates 4331291..4331596 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU739_RS18745 (HU739_018745) 4327980..4329194 + 1215 WP_186549700.1 aldose 1-epimerase family protein -
HU739_RS18750 (HU739_018750) 4329191..4330684 - 1494 WP_186549698.1 YifB family Mg chelatase-like AAA ATPase -
HU739_RS18755 (HU739_018755) 4331005..4331283 + 279 WP_186549755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU739_RS18760 (HU739_018760) 4331291..4331596 + 306 WP_186549696.1 HigA family addiction module antitoxin Antitoxin
HU739_RS18765 (HU739_018765) 4331710..4331970 - 261 WP_186549694.1 accessory factor UbiK family protein -
HU739_RS18770 (HU739_018770) 4332364..4332702 + 339 WP_002555808.1 P-II family nitrogen regulator -
HU739_RS18775 (HU739_018775) 4332740..4334077 + 1338 WP_186549692.1 ammonium transporter -
HU739_RS18780 (HU739_018780) 4334293..4334718 + 426 WP_186549690.1 secondary thiamine-phosphate synthase enzyme YjbQ -
HU739_RS18785 (HU739_018785) 4334821..4335147 + 327 WP_186549688.1 transcriptional regulator SutA -
HU739_RS18790 (HU739_018790) 4335325..4336032 - 708 WP_186549686.1 HAD-IA family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10419.97 Da        Isoelectric Point: 7.7181

>T206713 WP_186549755.1 NZ_CP077091:4331005-4331283 [Pseudomonas hamedanensis]
IMISFRCSETEYLFRSGKTRFWSAILSVAERKLTMLDAAAALADLRSPPGNRLETLGGDRKGQCSIRINAQWRICFVWGL
NGPEDVEIVDYH

Download         Length: 279 bp

>T206713 NZ_CP102665:327870-328307 [Sphingobium sp. JS3065]
GTGACCTATCTTCTCGACGTCAATGTGCTCGTTGCTCTGATCGATCCCAATCATGTCGGCCATGATGCCGCGCATCACTG
GTTCGAGTCCATCGGCGCCAGGGCCTGGGCGACGTGCCCCATCACCGAAAATGGGGTCATCCGCATCGTGGGGAACGTCA
AATATCCCTCGACCCCCGGTTCGCCAGCCGAGGTGGCGCGCATCATCGGGCAGATGCGGCAGTTGCCAGGGCACAGCTTC
TGGGCTGACGATATCAGCCTGCTGTCCGACGAGCGGGTCGACGAGAGCCGGCTTCTCACCTCTGCGCAGGTTACCGACAC
CTATCTCCTCGCGCTTGCCGTGGCGCATGATGGCAAGCTTGCCACCTTCGACCGGCGGCTCTCGCCCAGGGCCGTCAGCG
GCGGCAAGGCAGCCCTCCACCTCATCGGACATCAATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11287.02 Da        Isoelectric Point: 6.4556

>AT206713 WP_186549696.1 NZ_CP077091:4331291-4331596 [Pseudomonas hamedanensis]
MTKNGMRPVHPGEILKEEYLEPLNLTAAALARALNVSTPTVNDIVLQRRGISADMALRLSICLDTTPEFWLNLQSTYDLR
KAEIERGAAIRDQVERLAHCA

Download         Length: 306 bp

>AT206713 NZ_CP102665:327649-327873 [Sphingobium sp. JS3065]
ATGCGTACGACACTGGTCATAGATGATGATGTGATGGAAGCCGCGCGCGCCATCGCGGAGCATCAGAACCGTTCGATCGG
CCAGGTCGTTTCCGATCTGGCCCGGCGCTCGCTGCGCGCCCCCGAAGCCGCACGCAGCCGCAACGGCATCGCCCTCCTCG
CCGCGAAACCCGGCGTCGTGGTGACGCCAGAGATCGTAAATGCGCTGCGAGACGAGGCGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References