206693

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 6161625..6162297 Replicon chromosome
Accession NZ_CP077086
Organism Pseudomonas zarinae strain SWRI108

Toxin (Protein)


Gene name higB Uniprot ID A0A0F4XLD8
Locus tag HU749_RS27310 Protein ID WP_024616744.1
Coordinates 6161932..6162297 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0F4XJJ2
Locus tag HU749_RS27305 Protein ID WP_024616743.1
Coordinates 6161625..6161939 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU749_RS27285 (HU749_027285) 6157001..6157720 + 720 WP_046064546.1 protocatechuate 3,4-dioxygenase subunit beta -
HU749_RS27290 (HU749_027290) 6157733..6158335 + 603 WP_186652120.1 protocatechuate 3,4-dioxygenase subunit alpha -
HU749_RS29330 6158642..6159070 + 429 WP_225919114.1 hypothetical protein -
HU749_RS27295 (HU749_027295) 6159089..6161005 + 1917 WP_225919115.1 hypothetical protein -
HU749_RS27300 (HU749_027300) 6161042..6161503 + 462 WP_018607342.1 Lrp/AsnC family transcriptional regulator -
HU749_RS27305 (HU749_027305) 6161625..6161939 - 315 WP_024616743.1 XRE family transcriptional regulator Antitoxin
HU749_RS27310 (HU749_027310) 6161932..6162297 - 366 WP_024616744.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU749_RS27315 (HU749_027315) 6162660..6164342 + 1683 WP_186652122.1 NAD(P)/FAD-dependent oxidoreductase -
HU749_RS27320 (HU749_027320) 6164355..6165149 + 795 WP_079302823.1 carbon-nitrogen hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14256.94 Da        Isoelectric Point: 5.2125

>T206693 WP_024616744.1 NZ_CP077086:c6162297-6161932 [Pseudomonas zarinae]
MKWDVEYTDEFELWWDRLSESEQDSVQVSVMLLGDTGPYLGFPHTSDIKGSRHGNLRELRVQHAGRPYRVLYAFDPRRCA
ILLIGGDKTGQDRWYQQYVPLAERLYDEHLEVLKREGFDHG

Download         Length: 366 bp

>T206693 NZ_CP102602:c1219012-1218647 [Thermococcus sp. 813A4]
GTGAAAGTCGTTTTGCAGGAGCCGGGTTGGGAAGAAGTACCAACGGAGCCACACGTGGCAACGCTCGACTATGCACTCGT
TGAGGGCATGAACGCAATCTGGAAGGCAGTGCGACTCGGAGAGCTACTCATTGAGCAGGGAAAGGTTAAGGTAATCGTTC
TTAAGACGTTAGGGAGTTCGATAACACTCTTTGAGGCGCACAACTTCTTCGAGAGGGGGCTGGAAATCGGCCTGAATGAA
GGAATTACAATCTACGACGCCCTTTACATAGCCCTGGCCGAGGCGCTGAACGCGGAATTTCTGACTGCGGACGAGAAACA
GTATCTAGCCGCCAAAAATTATGTAAATGCCAAGCTCCTTCGTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11899.64 Da        Isoelectric Point: 9.6213

>AT206693 WP_024616743.1 NZ_CP077086:c6161939-6161625 [Pseudomonas zarinae]
MAKKFSDLMARRSPDSQARAQALYQQLRAEMPLHELRQAQELSQEALAKALHINQAAVSKMERRTDMYISTLRNYIRAMG
GELEIIATFPEGQVRIENFSHPTP

Download         Length: 315 bp

>AT206693 NZ_CP102602:c1219247-1219026 [Thermococcus sp. 813A4]
ATGGCCATCGTTACCGTCCGCGTTCCCGACGAGCTGAAGCTCAAGATGAAGGAGCTCAACATCAACTGGAGCGAGGAGAT
AAGGGAGTTCATAAGGAAGCGCATAGATGAGATAGAAAGAAAGAGACGAATACAGGAAGCCTTAGAGCTTGCAAAGGCCA
GCGGAAGCGTGAGCAGGGGTTTCGCAGCGAAGTCCGTGAGGGAGGACCGTGATAGTCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F4XLD8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F4XJJ2

References