Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 967689..968383 Replicon chromosome
Accession NC_003143
Organism Yersinia pestis CO92

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag YPO_RS05340 Protein ID WP_002214787.1
Coordinates 968087..968383 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag YPO_RS05335 Protein ID WP_002209924.1
Coordinates 967689..968087 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPO_RS05300 962879..963244 + 366 WP_002209919.1 hypothetical protein -
YPO_RS05305 963257..963493 + 237 WP_002214792.1 hypothetical protein -
YPO_RS05310 963499..963831 + 333 WP_002214791.1 hypothetical protein -
YPO_RS05315 964013..964213 + 201 WP_002209920.1 AlpA family transcriptional regulator -
YPO_RS05320 964227..964379 - 153 WP_002209921.1 hypothetical protein -
YPO_RS05325 964372..964698 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
YPO_RS05330 964998..967289 + 2292 WP_002209923.1 toprim domain-containing protein -
YPO_RS05335 967689..968087 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
YPO_RS05340 968087..968383 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
YPO_RS05345 968547..968909 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
YPO_RS05350 968972..969232 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
YPO_RS05355 969830..970015 + 186 WP_002209928.1 hypothetical protein -
YPO_RS05360 970097..971311 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
YPO_RS05370 971744..973261 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T20667 WP_002214787.1 NC_003143:c968383-968087 [Yersinia pestis CO92]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T20667 NC_003143:c968383-968087 [Yersinia pestis CO92]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT20667 WP_002209924.1 NC_003143:c968087-967689 [Yersinia pestis CO92]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT20667 NC_003143:c968087-967689 [Yersinia pestis CO92]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References