Detailed information of TA system TA206667

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3887650..3888313
• Replicon: chromosome
• Accession: NZ_CP077082
• Organism: Pseudomonas sp. OE 28.3

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: HU759_RS17300
• Protein ID: WP_080593813.1
• Coordinates: 3887948..3888313 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: HU759_RS17295
• Protein ID: WP_017139630.1
• Coordinates: 3887650..3887955 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU759_RS17270 (HU759_017270)	3882866..3884419	-	1554	WP_017139625.1	DUF726 domain-containing protein	-
HU759_RS17275 (HU759_017275)	3884507..3885289	-	783	WP_169986385.1	helix-turn-helix transcriptional regulator	-
HU759_RS17280 (HU759_017280)	3885389..3886261	+	873	WP_017139627.1	amino acid metabolite efflux pump	-
HU759_RS17285 (HU759_017285)	3886343..3886744	+	402	WP_170039707.1	RidA family protein	-
HU759_RS17290 (HU759_017290)	3886734..3887630	-	897	WP_170039709.1	LysR family transcriptional regulator	-
HU759_RS17295 (HU759_017295)	3887650..3887955	-	306	WP_017139630.1	XRE family transcriptional regulator	Antitoxin
HU759_RS17300 (HU759_017300)	3887948..3888313	-	366	WP_080593813.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (30-86)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13873.62 Da
• Isoelectric Point: 6.6953

>T206667 WP_080593813.1 NZ_CP077082:c3888313-3887948 [Pseudomonas sp. OE 28.3]
MDWDVEYTDEFAEWWDELGAKEQVSVSASVDLLGLFGPGLGFPHTSDIKGSRHGNLRELRVRHAGRPYRVLYAFDPRRCA
VLLIGGDKAAHPRWYEVHVPLAENVYDIHLQTLRKEARHHG

Nucleotide

• Length: 366 bp

>T206667 NZ_CP102552:c4717667-4717383 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11631.41 Da
• Isoelectric Point: 9.6558

>AT206667 WP_017139630.1 NZ_CP077082:c3887955-3887650 [Pseudomonas sp. OE 28.3]
MAKKFAELQARMTPQSRAEAEQLFRQHLKEMPLHELRKAQQLSQESLAKALNINQAAVSKMERRTDMYISTLRDYIRAMG
GELEIIATFPDGQVKIDNFAH

Nucleotide

• Length: 306 bp

>AT206667 NZ_CP102552:c4717899-4717657 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA