206644

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5854961..5855624 Replicon chromosome
Accession NZ_CP077078
Organism Pseudomonas azerbaijanoriens strain SWRI123

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KSS91_RS26340 Protein ID WP_102674224.1
Coordinates 5855259..5855624 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID J3BKI2
Locus tag KSS91_RS26335 Protein ID WP_008051594.1
Coordinates 5854961..5855266 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS91_RS26325 (KSS91_26325) 5851048..5854794 + 3747 WP_217836524.1 EAL domain-containing protein -
KSS91_RS26335 (KSS91_26335) 5854961..5855266 - 306 WP_008051594.1 XRE family transcriptional regulator Antitoxin
KSS91_RS26340 (KSS91_26340) 5855259..5855624 - 366 WP_102674224.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KSS91_RS26345 (KSS91_26345) 5856203..5856523 + 321 WP_217836525.1 DUF3077 domain-containing protein -
KSS91_RS26350 (KSS91_26350) 5856592..5857194 + 603 WP_217836526.1 nucleotidyltransferase domain-containing protein -
KSS91_RS26355 (KSS91_26355) 5857184..5857612 + 429 WP_217836527.1 hypothetical protein -
KSS91_RS26360 (KSS91_26360) 5857629..5858309 - 681 WP_217838476.1 peptidase M41 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(6-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14076.60 Da        Isoelectric Point: 4.6964

>T206644 WP_102674224.1 NZ_CP077078:c5855624-5855259 [Pseudomonas azerbaijanoriens]
MKWDVEYTDEFEAWWDRLNEAEQDSVQATVMLLGEDGPHLGFPHTSDIKGSRHGNLRELRVQHAGRPYRVLYAFDPRRSA
ILLIGGDKTGQERWYAENVPLAERLYDEHLETLMKEGYDNG

Download         Length: 366 bp

>T206644 NZ_CP102546:219017-219119 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11521.29 Da        Isoelectric Point: 10.4463

>AT206644 WP_008051594.1 NZ_CP077078:c5855266-5854961 [Pseudomonas azerbaijanoriens]
MAKKFADLVARRSPESQARVEALHQKLRAQMPLHELRQAQALSQDTLARTLHVNQAAISKMERRTDMYISTLRNYIRAMG
GELEIIATFPEGQVKIENFAN

Download         Length: 306 bp

>AT206644 NZ_CP102546:c219126-218981 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB J3BKI2

References