Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 748340..749034 Replicon chromosome
Accession NZ_CP077074
Organism Pseudomonas sessilinigenes strain CMR12a

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KSS89_RS03375 Protein ID WP_124345580.1
Coordinates 748340..748636 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KSS89_RS03380 Protein ID WP_022640300.1
Coordinates 748633..749034 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS89_RS03340 (KSS89_03340) 743971..744516 - 546 WP_124345577.1 hypothetical protein -
KSS89_RS03345 (KSS89_03345) 744513..744767 - 255 WP_068578636.1 acyl carrier protein -
KSS89_RS03350 (KSS89_03350) 744777..745049 - 273 WP_068578634.1 phosphopantetheine-binding protein -
KSS89_RS03355 (KSS89_03355) 745018..745839 - 822 WP_124345578.1 lysophospholipid acyltransferase family protein -
KSS89_RS03360 (KSS89_03360) 745815..746543 - 729 WP_124345579.1 beta-ketoacyl synthase chain length factor -
KSS89_RS03365 (KSS89_03365) 746855..747625 + 771 WP_068578628.1 ParA family protein -
KSS89_RS03370 (KSS89_03370) 747677..748111 - 435 WP_068578626.1 thioredoxin TrxC -
KSS89_RS03375 (KSS89_03375) 748340..748636 + 297 WP_124345580.1 type II toxin-antitoxin system HigB family toxin Toxin
KSS89_RS03380 (KSS89_03380) 748633..749034 + 402 WP_022640300.1 transcriptional regulator Antitoxin
KSS89_RS03385 (KSS89_03385) 749036..750499 - 1464 WP_124345581.1 YdiU family protein -
KSS89_RS03390 (KSS89_03390) 750569..753895 - 3327 WP_124345582.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Antitoxin HigA

(15-133)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11552.39 Da        Isoelectric Point: 10.3534

>T206625 WP_124345580.1 NZ_CP077074:748340-748636 [Pseudomonas sessilinigenes]
MHIITAKRIWQAKEQWPQSARALDTWYRKAKGARPEDFSDMKALFPAVDKVGRFHVFDIGGNKLRLIALVRYGVQRLYIR
HVLDHASYDKGLWKEEIE

Download         Length: 297 bp

>T206625 NZ_CP102530:1379775-1380077 [Lacticaseibacillus paracasei subsp. paracasei]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCTGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCTT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTACATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTAAG
CAGCAAGATCTCATTTTGACCCTGGTTAGAACTGGATCTCATCATAACCTTTTGGGTAAATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14866.97 Da        Isoelectric Point: 4.4569

>AT206625 WP_022640300.1 NZ_CP077074:748633-749034 [Pseudomonas sessilinigenes]
MSILVSQAAEHWQFVAPLLRKPRTEADYDALALALDELLDIMGEDEAHPLASLVDIIGDWIEAYDEEHRPIPPVSGVEVL
RSLMHEHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQVRWLSERFKVAMEVFA

Download         Length: 402 bp

>AT206625 NZ_CP102530:1379513-1379782 [Lacticaseibacillus paracasei subsp. paracasei]
ATGGCAGCCACAAAGAAAGAAACTCGCTTGAATATTCGTGTTGATCCGGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACTATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References