Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1848291..1848895 Replicon chromosome
Accession NZ_CP077073
Organism Pseudomonas muyukensis strain COW39

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KSS95_RS08335 Protein ID WP_217853224.1
Coordinates 1848575..1848895 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KSS95_RS08330 Protein ID WP_217853222.1
Coordinates 1848291..1848578 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSS95_RS08320 (KSS95_08320) 1844293..1846656 + 2364 WP_217853221.1 TonB-dependent receptor -
KSS95_RS08325 (KSS95_08325) 1846664..1848265 + 1602 WP_225935569.1 alpha/beta hydrolase-fold protein -
KSS95_RS08330 (KSS95_08330) 1848291..1848578 - 288 WP_217853222.1 NadS family protein Antitoxin
KSS95_RS08335 (KSS95_08335) 1848575..1848895 - 321 WP_217853224.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KSS95_RS08340 (KSS95_08340) 1849026..1850726 - 1701 WP_217853226.1 SulP family inorganic anion transporter -
KSS95_RS08345 (KSS95_08345) 1850911..1851792 - 882 WP_217853228.1 transcriptional regulator CynR -
KSS95_RS08350 (KSS95_08350) 1851905..1852564 + 660 WP_217853230.1 carbonic anhydrase -
KSS95_RS08355 (KSS95_08355) 1852596..1853066 + 471 WP_217853232.1 cyanase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1848291..1866408 18117


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12023.86 Da        Isoelectric Point: 9.7526

>T206621 WP_217853224.1 NZ_CP077073:c1848895-1848575 [Pseudomonas muyukensis]
MLFTETAIFTKRVQERLDDESYRLLQVRLLICPDAGDTIEGTGGLRKIRVAAKGHGKRGGARVIYYHLVTASQIAMLYIY
PNNEQPNLNAEQRKALKAVIEHWSQP

Download         Length: 321 bp

>T206621 NZ_CP102514:3590470-3590892 [Streptomyces yangpuensis]
GTGAACGCGGCGCAGTTCCTGATCGACACCAGCGCGCTCGCGCGCTTCATGCGCAGGGATGCGGAGCAGTACGGCTGGGA
CCAGGCGGCAGCCGCCGGTCTCATCGCCACCTGTCCCATCACCGAGCTGGAGTTCTTCTACAGCGCCCGGTCCACAGCCG
ACCGGGCGCGCGGCATCGAGGACATGCGGCTGATCTTCGGCTGGGTTTCCGTCGACGACCGCGCCTACGACCGCGCCTGG
CAGGTCCAGGACGCCCTCACCAGGCAGGGGAAGCACCGAAGTGCCGGCGCCGTCGACCTCGTCGTCGCCGCGACAGCCGA
ACTCCAGGGGCTCACCCTCCTTCATCGCGACCACGACTTCGAGTGCATCGCGGCCGTGACTGGCCAGCCCCTCCAGTGGT
ACGGCCCGGAACACGGCAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10972.59 Da        Isoelectric Point: 10.2881

>AT206621 WP_217853222.1 NZ_CP077073:c1848578-1848291 [Pseudomonas muyukensis]
MNRFFDELMQSVEQMDVIVHGRRQPARQFEIDALQVKNIRKATGLSQTRFAEMIDVQVATLRNWEQGRREPTGPAKALLR
AIHNDPEHVLKALAH

Download         Length: 288 bp

>AT206621 NZ_CP102514:3590258-3590473 [Streptomyces yangpuensis]
ATGAGTCGGACCGTCATCGATCTGGACGACGAGCTGGTCGCCGACGTGGCGAAAGCCCTCGGAACGAGCACCAAGAAGGA
GACTGTCAACACCGCCCTGCGCGAGGTGCTGGAGAACCGGCGCCGCGCCCTGGCGCTCACCCGGCTCCGTGCCGCGGCCG
ACGAAGGCGCTTTCGACCTGGAGCTCTTCGAGAACAAGAGGAACTACCGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References