Detailed information of TA system TA206616

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 3848950..3849506
• Replicon: chromosome
• Accession: NZ_CP077072
• Organism: Luteibacter anthropi strain SM7.4

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KR767_RS16445
• Protein ID: WP_250877045.1
• Coordinates: 3849240..3849506 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KR767_RS16440
• Protein ID: WP_166946504.1
• Coordinates: 3848950..3849237 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KR767_RS16425 (KR767_16400)	3844857..3845042	+	186	WP_250877042.1	hypothetical protein	-
KR767_RS16430 (KR767_16405)	3845129..3847234	+	2106	WP_250877043.1	hypothetical protein	-
KR767_RS16435 (KR767_16410)	3847380..3848600	-	1221	WP_250877044.1	arabinose transporter	-
KR767_RS16440 (KR767_16415)	3848950..3849237	-	288	WP_166946504.1	helix-turn-helix domain-containing protein	Antitoxin
KR767_RS16445 (KR767_16420)	3849240..3849506	-	267	WP_250877045.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KR767_RS16450 (KR767_16425)	3849988..3850275	-	288	WP_250877046.1	hypothetical protein	-
KR767_RS16455 (KR767_16430)	3850962..3851804	-	843	WP_250877047.1	SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3844857..3860676	15819

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (26-83)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10069.48 Da
• Isoelectric Point: 9.8466

>T206616 WP_250877045.1 NZ_CP077072:c3849506-3849240 [Luteibacter anthropi]
VDDDNYAAFQQWLAQHPEAGDVIQNTGGLRKIRLACGGQGKRSGARVIYYHFVRRSHIAMLLVYPKNAMDDLTESQKKSL
KHLIDTWR

Nucleotide

• Length: 267 bp

>T206616 NZ_CP102509:3530079-3530342 [Streptomyces sp. NBC_00162]
GTGAGTGAGTACCGGACCGCCTTCCGCCCCGAGGCGCAGGCCGAGCTGCGCAAGATCCCGCGCGACATGGCGCTTCGCGT
CCTGGCCAAACTGACAGAGCTGGAGAGCGACCCCTTCGGCTTCAACACCACCGCACTCGTATCCCAGCCCGAACGACGCC
GCCTGCGCGTCGGCGACTACCGTTTCGTCTACACGATCGACAACGGGGAGCTGGTGGTGTGGGTCGTACACGTCGGACAC
CGCTCCACGGTCTACGGCACGTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10725.38 Da
• Isoelectric Point: 10.8838

>AT206616 WP_166946504.1 NZ_CP077072:c3849237-3848950 [Luteibacter anthropi]
MDKQLFAELMESVSQMDEIVRGKRKPSREFHVDPAGIREIRQATGLSQPKFAQMLSVDVGTLRNWEQGRREPTGPARALL
RAIRNDPVNVLKALA

Nucleotide

• Length: 288 bp

>AT206616 NZ_CP102509:3529817-3530086 [Streptomyces sp. NBC_00162]
ATGACACAGCCGCTGCCCGTAGAGTCCATCCGCGACGTGCGCGCGCACCTGGCCGAGGTCGTGGAGCGCGCCGATCGGGA
CGGCGTGCCGACGGTGATCACGCGCCGCGGCAAGGAAGTCGCCGCCGTCGTGTCGATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCGGCACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA