Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 32180..32795 | Replicon | chromosome |
| Accession | NZ_CP077061 | ||
| Organism | Vibrio cholerae strain MS84A | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | J3992_RS13845 | Protein ID | WP_001162670.1 |
| Coordinates | 32508..32795 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | J3992_RS13840 | Protein ID | WP_001232701.1 |
| Coordinates | 32180..32497 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3992_RS13790 (J3992_13775) | 27589..28050 | - | 462 | WP_001911752.1 | lipocalin family protein | - |
| J3992_RS13795 (J3992_13780) | 28241..28717 | - | 477 | WP_001047180.1 | GNAT family N-acetyltransferase | - |
| J3992_RS13800 (J3992_13785) | 28745..28855 | - | 111 | WP_071917832.1 | DUF3265 domain-containing protein | - |
| J3992_RS13805 (J3992_13790) | 28852..29781 | - | 930 | WP_000335802.1 | hypothetical protein | - |
| J3992_RS13810 (J3992_13795) | 29901..30347 | - | 447 | WP_000128977.1 | hypothetical protein | - |
| J3992_RS13815 (J3992_13800) | 30500..31504 | - | 1005 | WP_000964925.1 | LD-carboxypeptidase | - |
| J3992_RS13820 | 31692..31808 | - | 117 | WP_001889170.1 | hypothetical protein | - |
| J3992_RS13825 (J3992_13805) | 31771..31896 | - | 126 | WP_001944767.1 | DUF645 family protein | - |
| J3992_RS13830 (J3992_13810) | 31924..32034 | - | 111 | Protein_66 | acetyltransferase | - |
| J3992_RS13835 (J3992_13815) | 32073..32183 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| J3992_RS13840 (J3992_13820) | 32180..32497 | - | 318 | WP_001232701.1 | HigA family addiction module antitoxin | Antitoxin |
| J3992_RS13845 (J3992_13825) | 32508..32795 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J3992_RS13850 (J3992_13830) | 32836..32949 | - | 114 | WP_001894955.1 | hypothetical protein | - |
| J3992_RS13855 (J3992_13835) | 33062..33242 | - | 181 | Protein_71 | DUF645 family protein | - |
| J3992_RS13860 (J3992_13840) | 33667..33900 | - | 234 | WP_032482776.1 | DUF3709 domain-containing protein | - |
| J3992_RS13865 (J3992_13845) | 33921..34114 | - | 194 | Protein_73 | hypothetical protein | - |
| J3992_RS13870 (J3992_13850) | 34303..34521 | - | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| J3992_RS13875 (J3992_13855) | 34533..34742 | - | 210 | WP_001900246.1 | DUF3709 domain-containing protein | - |
| J3992_RS13880 (J3992_13860) | 34831..35484 | - | 654 | WP_000226874.1 | hypothetical protein | - |
| J3992_RS13885 (J3992_13865) | 35541..36050 | - | 510 | WP_000405987.1 | GNAT family N-acetyltransferase | - |
| J3992_RS13890 (J3992_13870) | 36292..36534 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| J3992_RS13895 (J3992_13875) | 36553..36870 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J3992_RS13900 (J3992_13880) | 37064..37216 | - | 153 | Protein_80 | DUF645 family protein | - |
| J3992_RS13905 (J3992_13885) | 37277..37452 | - | 176 | Protein_81 | acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 1..1044173 | 1044172 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T206606 WP_001162670.1 NZ_CP077061:c32795-32508 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T206606 NZ_CP102500:c4833727-4833353 [Citrobacter youngae]
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGACCTGTTTAGTGGACGGAGTGAAGCAAAGCAAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AATCCCGCACACGCGTTGCGTTGAGCGCTTTTAACGTGATCGGTGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTACCGGATGCCATTATTTTGGCAACAGCACAGATTCATCGCCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGACCTGTTTAGTGGACGGAGTGAAGCAAAGCAAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AATCCCGCACACGCGTTGCGTTGAGCGCTTTTAACGTGATCGGTGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTACCGGATGCCATTATTTTGGCAACAGCACAGATTCATCGCCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT206606 WP_001232701.1 NZ_CP077061:c32497-32180 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT206606 NZ_CP102500:c4833969-4833727 [Citrobacter youngae]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATTAAACGTCTTGATGACCTCAAGGT
GCAGCGTAACCTGCCGCGAGCTGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGGCAGGAACAGGCTGAAACGA
CTATTTCCAGCGCTCTCGGACTCTGGAAAGGTTGTGAAGAAGATGGCGTTGAGTACCAACGCAAACTTCGTGAGGAATGG
TAA
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATTAAACGTCTTGATGACCTCAAGGT
GCAGCGTAACCTGCCGCGAGCTGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGGCAGGAACAGGCTGAAACGA
CTATTTCCAGCGCTCTCGGACTCTGGAAAGGTTGTGAAGAAGATGGCGTTGAGTACCAACGCAAACTTCGTGAGGAATGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|