20660

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1566450..1566962 Replicon chromosome
Accession NC_003098
Organism Streptococcus pneumoniae R6

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag SPR_RS07860 Protein ID WP_000924721.1
Coordinates 1566450..1566704 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag SPR_RS07865 Protein ID WP_000388572.1
Coordinates 1566708..1566962 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPR_RS07845 (spr1582) 1563551..1563865 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
SPR_RS07850 (spr1583) 1563890..1564516 - 627 WP_000775044.1 guanylate kinase -
SPR_RS07855 (spr1584) 1564646..1566259 - 1614 WP_000404940.1 ribonuclease Y -
SPR_RS07860 (spr1585) 1566450..1566704 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
SPR_RS07865 (spr1586) 1566708..1566962 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SPR_RS07870 (spr1587) 1567200..1568297 - 1098 WP_000156355.1 nucleotidyltransferase -
SPR_RS07875 (spr1588) 1568307..1569053 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
SPR_RS07880 (spr1589) 1569156..1569509 - 354 WP_001003001.1 ribosome silencing factor -
SPR_RS07885 (spr1590) 1569522..1570022 - 501 WP_000844717.1 cysteine hydrolase -
SPR_RS07890 (spr1591) 1570023..1570616 - 594 WP_000121655.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
SPR_RS07895 (spr1592) 1570616..1571245 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
SPR_RS07900 (spr1593) 1571297..1571608 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T20660 WP_000924721.1 NC_003098:c1566704-1566450 [Streptococcus pneumoniae R6]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T20660 NC_003098:c1566704-1566450 [Streptococcus pneumoniae R6]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT20660 WP_000388572.1 NC_003098:c1566962-1566708 [Streptococcus pneumoniae R6]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT20660 NC_003098:c1566962-1566708 [Streptococcus pneumoniae R6]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGCCCAAAATAAGGAGTTATCAGACAAGGTTTTACGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTCCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References