Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 4221724..4222397 | Replicon | chromosome |
| Accession | NZ_CP076851 | ||
| Organism | Mycobacterium avium subsp. hominissuis strain CAM177 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A2A2ZF02 |
| Locus tag | BB735_RS19730 | Protein ID | WP_033718548.1 |
| Coordinates | 4221724..4222071 (+) | Length | 116 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A2A2ZDH9 |
| Locus tag | BB735_RS19735 | Protein ID | WP_033718509.1 |
| Coordinates | 4222068..4222397 (+) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BB735_RS19705 (BB735_019705) | 4217321..4217746 | + | 426 | WP_129560155.1 | hypothetical protein | - |
| BB735_RS19710 (BB735_019710) | 4217791..4218950 | + | 1160 | WP_085989675.1 | IS3 family transposase | - |
| BB735_RS19715 (BB735_019715) | 4219338..4220186 | + | 849 | WP_076221054.1 | helix-turn-helix domain-containing protein | - |
| BB735_RS19720 (BB735_019720) | 4220164..4220346 | + | 183 | WP_225345502.1 | helix-turn-helix domain-containing protein | - |
| BB735_RS19725 (BB735_019725) | 4220373..4221671 | + | 1299 | WP_231100688.1 | tyrosine-type recombinase/integrase | - |
| BB735_RS19730 (BB735_019730) | 4221724..4222071 | + | 348 | WP_033718548.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| BB735_RS19735 (BB735_019735) | 4222068..4222397 | + | 330 | WP_033718509.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| BB735_RS19740 (BB735_019740) | 4222599..4223201 | + | 603 | WP_129560154.1 | hypothetical protein | - |
| BB735_RS19745 (BB735_019745) | 4223198..4223650 | + | 453 | WP_033718506.1 | GNAT family N-acetyltransferase | - |
| BB735_RS19750 (BB735_019750) | 4223715..4224410 | + | 696 | WP_225345503.1 | hypothetical protein | - |
| BB735_RS19755 (BB735_019755) | 4224529..4226067 | + | 1539 | WP_062887722.1 | IS21 family transposase | - |
| BB735_RS19760 (BB735_019760) | 4226131..4226886 | + | 756 | WP_062887723.1 | IS21-like element helper ATPase IstB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4214368..4239488 | 25120 | |
| - | flank | IS/Tn | - | - | 4226131..4226886 | 755 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 12988.78 Da Isoelectric Point: 4.3961
>T206564 WP_033718548.1 NZ_CP076851:4221724-4222071 [Mycobacterium avium subsp. hominissuis]
MSWDVILLEEVETWYFSLDEDAMAAVTGAIDLLELEGPTLGRPTVDKVKGSKFHSMKELRPAGTSIRILFIFDPRRQAIL
LLGGDKAGNWKSWYDKNIPIAERSYEDWLATEGGE
MSWDVILLEEVETWYFSLDEDAMAAVTGAIDLLELEGPTLGRPTVDKVKGSKFHSMKELRPAGTSIRILFIFDPRRQAIL
LLGGDKAGNWKSWYDKNIPIAERSYEDWLATEGGE
Download Length: 348 bp
>T206564 NZ_CP102488:1810553-1810939 [Escherichia coli O15:H18]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 110 a.a. Molecular weight: 11922.43 Da Isoelectric Point: 7.4050
>AT206564 WP_033718509.1 NZ_CP076851:4222068-4222397 [Mycobacterium avium subsp. hominissuis]
MSMARNWRDIRADAIAQGRLDPARADAARNEMHDAVQAHRLAEIRKAQGHRRQADVAVLMGVSQARVSKLESGDLSHTEL
GTLQSYVAALGGSLRVVAEFDEKTVELTT
MSMARNWRDIRADAIAQGRLDPARADAARNEMHDAVQAHRLAEIRKAQGHRRQADVAVLMGVSQARVSKLESGDLSHTEL
GTLQSYVAALGGSLRVVAEFDEKTVELTT
Download Length: 330 bp
>AT206564 NZ_CP102488:1810929-1811258 [Escherichia coli O15:H18]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGACCGGAAGTTTT
TGCAAAGTAA
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGAAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGACCGGAAGTTTT
TGCAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A2ZF02 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A2ZDH9 |