Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 213986..214622 Replicon chromosome
Accession NZ_CP076847
Organism Agrobacterium pusense strain SX41

Toxin (Protein)


Gene name graT Uniprot ID A0A098RNJ2
Locus tag KP800_RS15885 Protein ID WP_006697304.1
Coordinates 214341..214622 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag KP800_RS15880 Protein ID WP_004444714.1
Coordinates 213986..214285 (-) Length 100 a.a.

Genomic Context

KP800_RS15875KP800_RS26750KP800_RS15855KP800_RS15860KP800_RS15865KP800_RS15870KP800_RS15880KP800_RS15885KP800_RS15890KP800_RS15895KP800_RS15900KP800_RS15905
Location: 213092..213799 (708 bp)
Type: Others
Protein ID: WP_234797374.1
Location: 213709..213966 (258 bp)
Type: Others
Protein ID: WP_234797373.1
Location: 209172..209900 (729 bp)
Type: Others
Protein ID: WP_037092566.1
Location: 209897..210805 (909 bp)
Type: Others
Protein ID: WP_037092567.1
Location: 210802..211674 (873 bp)
Type: Others
Protein ID: WP_037092568.1
Location: 211745..212959 (1215 bp)
Type: Others
Protein ID: WP_037092569.1
Location: 213986..214285 (300 bp)
Type: Antitoxin
Protein ID: WP_004444714.1
Location: 214341..214622 (282 bp)
Type: Toxin
Protein ID: WP_006697304.1
Location: 214697..215506 (810 bp)
Type: Others
Protein ID: WP_037092570.1
Location: 215503..216471 (969 bp)
Type: Others
Protein ID: WP_037092571.1
Location: 216474..217517 (1044 bp)
Type: Others
Protein ID: WP_037092572.1
Location: 217514..218521 (1008 bp)
Type: Others
Protein ID: WP_037092598.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KP800_RS15855 (KP800_15855)209172..209900-729WP_037092566.1ABC transporter ATP-binding protein-
KP800_RS15860 (KP800_15860)209897..210805-909WP_037092567.1branched-chain amino acid ABC transporter permease-
KP800_RS15865 (KP800_15865)210802..211674-873WP_037092568.1branched-chain amino acid ABC transporter permease-
KP800_RS15870 (KP800_15870)211745..212959-1215WP_037092569.1amino acid ABC transporter substrate-binding protein-
KP800_RS15875 (KP800_15875)213092..213799+708WP_234797374.1hypothetical protein-
KP800_RS26750213709..213966+258WP_234797373.1helix-turn-helix transcriptional regulator-
KP800_RS15880 (KP800_15880)213986..214285-300WP_004444714.1HigA family addiction module antitoxinAntitoxin
KP800_RS15885 (KP800_15885)214341..214622-282WP_006697304.1type II toxin-antitoxin system RelE/ParE family toxinToxin
KP800_RS15890 (KP800_15890)214697..215506-810WP_037092570.1ABC transporter ATP-binding protein-
KP800_RS15895 (KP800_15895)215503..216471-969WP_037092571.1iron chelate uptake ABC transporter family permease subunit-
KP800_RS15900 (KP800_15900)216474..217517-1044WP_037092572.1iron ABC transporter permease-
KP800_RS15905 (KP800_15905)217514..218521-1008WP_037092598.1iron-siderophore ABC transporter substrate-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10536.95 Da        Isoelectric Point: 9.0298

>T206558 WP_006697304.1 NZ_CP076847:c214622-214341 [Agrobacterium pusense]
MIRSFKNKLAASIDDGSVKKGFPSDMLRRAQQLLTVLDAATTVEDPRSPPGNRLEKLSGDREGQYSIRINKQWRICFVWT
QAGPESVEITDYH

Download         Length: 282 bp

>T206558 NZ_CP102488:1069948-1071270 [Escherichia coli O15:H18]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACTGTCGCTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11060.86 Da        Isoelectric Point: 8.5148

>AT206558 WP_004444714.1 NZ_CP076847:c214285-213986 [Agrobacterium pusense]
MTISKSPPIHPGEILRELYLEPLGMSAYALARHLNVPRTRIERIAGEKLGITADTALRLAKFFKTTPEYWLNLQNAFDIK
AAAARLETDLANIKELEAA

Download         Length: 300 bp

>AT206558 NZ_CP102488:1069682-1069948 [Escherichia coli O15:H18]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGTATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A098RNJ2

Antitoxin

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Source
ID
Structure
No matching records found

References