Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-YefM
Location 1743975..1744495 Replicon chromosome
Accession NZ_CP076846
Organism Agrobacterium pusense strain SX41

Toxin (Protein)


Gene name yoeB Uniprot ID A0A098RUX8
Locus tag KP800_RS08970 Protein ID WP_037089950.1
Coordinates 1743975..1744244 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A098RWL5
Locus tag KP800_RS08975 Protein ID WP_037089948.1
Coordinates 1744241..1744495 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP800_RS08950 (KP800_08950) 1738981..1740675 - 1695 WP_037089954.1 iron ABC transporter permease -
KP800_RS08955 (KP800_08955) 1740685..1741668 - 984 WP_037089952.1 ABC transporter substrate-binding protein -
KP800_RS08960 (KP800_08960) 1742004..1743248 - 1245 WP_004442697.1 PLP-dependent aminotransferase family protein -
KP800_RS08965 (KP800_08965) 1743521..1743970 + 450 WP_037089951.1 RbsD/FucU family protein -
KP800_RS08970 (KP800_08970) 1743975..1744244 - 270 WP_037089950.1 Txe/YoeB family addiction module toxin Toxin
KP800_RS08975 (KP800_08975) 1744241..1744495 - 255 WP_037089948.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KP800_RS08980 (KP800_08980) 1744633..1745652 - 1020 WP_003495030.1 ketol-acid reductoisomerase -
KP800_RS08985 (KP800_08985) 1745702..1746355 - 654 WP_004442706.1 TetR/AcrR family transcriptional regulator -
KP800_RS08990 (KP800_08990) 1746752..1747657 - 906 WP_037089946.1 AraC family transcriptional regulator -
KP800_RS08995 (KP800_08995) 1747847..1748896 + 1050 WP_037089944.1 NAD(P)-dependent alcohol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10612.09 Da        Isoelectric Point: 9.8742

>T206557 WP_037089950.1 NZ_CP076846:c1744244-1743975 [Agrobacterium pusense]
MKLVWTLSSWDDYEFWQRTDARMVEKINDLIRNAKRTPFAGLGKPEPLKGDMAGYWSRRISAEHRFVYRVSGSGSEQRLE
IIQCRFHYQ

Download         Length: 270 bp

>T206557 NZ_CP102488:714269-714372 [Escherichia coli O15:H18]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9702.92 Da        Isoelectric Point: 4.6631

>AT206557 WP_037089948.1 NZ_CP076846:c1744495-1744241 [Agrobacterium pusense]
MANVRFTEFRQNFATHFDRVLETRAPLLVTRQGKEAVVVLAEGEYESMQETLHLLSNPANALRLRTSMDQLERGDIIERD
PTEE

Download         Length: 255 bp

>AT206557 NZ_CP102488:c714410-714139 [Escherichia coli O15:H18]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A098RUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A098RWL5

References