Detailed information of TA system TA206543

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2792567..2793146
• Replicon: chromosome
• Accession: NZ_CP076839
• Organism: Staphylococcus aureus strain 55-100-016

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: KRH48_RS13570
• Protein ID: WP_001025401.1
• Coordinates: 2792567..2792812 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2792781..2793146 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KRH48_RS13525 (KRH48_13525)	2788024..2789229	-	1206	WP_031585161.1	tyrosine-type recombinase/integrase	-
KRH48_RS13530 (KRH48_13530)	2789355..2789969	+	615	WP_031863779.1	hypothetical protein	-
KRH48_RS13535 (KRH48_13535)	2789966..2790112	-	147	WP_001013104.1	hypothetical protein	-
KRH48_RS13540 (KRH48_13540)	2790342..2790926	-	585	WP_000825948.1	hypothetical protein	-
KRH48_RS13545 (KRH48_13545)	2790944..2791405	-	462	WP_000525004.1	hypothetical protein	-
KRH48_RS13550 (KRH48_13550)	2791418..2791741	-	324	WP_001260485.1	helix-turn-helix transcriptional regulator	-
KRH48_RS13555 (KRH48_13555)	2791905..2792153	+	249	WP_000272860.1	helix-turn-helix transcriptional regulator	-
KRH48_RS13560 (KRH48_13560)	2792169..2792312	+	144	WP_000939498.1	hypothetical protein	-
KRH48_RS13565 (KRH48_13565)	2792302..2792511	-	210	WP_000642492.1	hypothetical protein	-
KRH48_RS13570 (KRH48_13570)	2792567..2792812	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
KRH48_RS13575 (KRH48_13575)	2792781..2793146	-	366	WP_001128433.1	hypothetical protein	Antitoxin
KRH48_RS13580 (KRH48_13580)	2793201..2793416	+	216	WP_001036302.1	hypothetical protein	-
KRH48_RS13585 (KRH48_13585)	2793441..2793704	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
KRH48_RS13590 (KRH48_13590)	2793717..2793878	+	162	WP_001285963.1	DUF1270 family protein	-
KRH48_RS13595 (KRH48_13595)	2793957..2794280	+	324	WP_000174994.1	hypothetical protein	-
KRH48_RS13600 (KRH48_13600)	2794295..2794657	+	363	WP_031863778.1	hypothetical protein	-
KRH48_RS13605 (KRH48_13605)	2794654..2795820	+	1167	WP_031863777.1	DUF2800 domain-containing protein	-
KRH48_RS13610 (KRH48_13610)	2795846..2796403	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2785032..2809427	24395

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T206543 WP_001025401.1 NZ_CP076839:2792567-2792812 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T206543 NZ_CP102483:c1277737-1277471 [Burkholderia contaminans]
ATGAGTGTACGCCGCGTGCTCGTTACTTCCGACGCGTGGGACGACTATGTCTACTGGCAGGGGCAGGATCGCAAGACGCT
CAAGCGTATCAACCAGCTCATTCGCGAAGCCCAGCGAACGCCGTTCGAAGGCATCGGCAAACCCGAACCGTTAAAGGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGACACGAACCGTCTGGTCTACGAGGCTGACGACTTGCAGATCAGCATC
GTGTCCTGCCGTTACCACTACGAATAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT206543 NZ_CP076839:c2793146-2792781 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin