Detailed information of TA system TA206511

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2441519..2441703
• Replicon: chromosome
• Accession: NZ_CP076823
• Organism: Staphylococcus aureus strain ST59

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KQY23_RS12035
• Protein ID: WP_000482647.1
• Coordinates: 2441596..2441703 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2441519..2441579 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQY23_RS12015	2437029..2437196	-	168	WP_031845053.1	hypothetical protein	-
KQY23_RS12020	2437427..2439160	-	1734	Protein_2334	ABC transporter ATP-binding protein/permease	-
KQY23_RS12025	2439236..2440948	-	1713	WP_216753080.1	ABC transporter ATP-binding protein	-
KQY23_RS12030	2441402..2441569	-	168	WP_000301893.1	hypothetical protein	-
-	2441519..2441579	+	61	-	-	Antitoxin
KQY23_RS12035	2441596..2441703	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
KQY23_RS12040	2441836..2442222	-	387	WP_000779353.1	flippase GtxA	-
KQY23_RS12045	2442490..2443632	+	1143	WP_001176863.1	glycerate kinase	-
KQY23_RS12050	2443692..2444351	+	660	WP_000831298.1	membrane protein	-
KQY23_RS12055	2444534..2445745	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
KQY23_RS12060	2445868..2446341	-	474	WP_000456483.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T206511 WP_000482647.1 NZ_CP076823:c2441703-2441596 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T206511 NZ_CP102465:66841-67251 [Burkholderia contaminans]
ATGACGCTGTACCTGCTCGATACCAACATTTTGTCGAACGTGATCCGCGACCCGCGCGGCGCATGCGCCACCCGGATTGG
AGAAACGCCGCCCGAACAAGTGTGCACCTCGATCATCGTGGCCGCGGAATTGCGGTTCGGCGTCTGGAAGCGTGGCTCGT
CAACGCTCGCGCAGCGCGTCGAGCAGCTGCTCGCAAGCCTGACCGTGTTGCCGCTGCAACCGGACGCGGACCGCTGCTAC
GGGCGGTTGCGGGCCGAGCTCGAGAAGCAAGGCCAGTTGATCGACGCCAACGACATGCTGATCGCCGCGCATGCGCTGGC
CGTCGACGCCGTGCTGGTCACGGACAACACGGCTGAATTCACCCGTATCGCGGGGCTGCCGGTCGAAAACTGGCTGCGGC
CGGCGACGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT206511 NZ_CP076823:2441519-2441579 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin