Detailed information of TA system TA206510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2416248..2416765
• Replicon: chromosome
• Accession: NZ_CP076823
• Organism: Staphylococcus aureus strain ST59

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2S6D1N9
• Locus tag: KQY23_RS11895
• Protein ID: WP_000113263.1
• Coordinates: 2416248..2416514 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: KQY23_RS11900
• Protein ID: WP_000584499.1
• Coordinates: 2416514..2416765 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQY23_RS11870 (2411508)	2411508..2412044	-	537	WP_000185901.1	GNAT family N-acetyltransferase	-
KQY23_RS11875 (2412457)	2412457..2413281	-	825	WP_000594633.1	formate/nitrite transporter family protein	-
KQY23_RS11880 (2413485)	2413485..2413667	-	183	WP_000079140.1	hypothetical protein	-
KQY23_RS11885 (2413754)	2413754..2414221	-	468	WP_000153338.1	SRPBCC domain-containing protein	-
KQY23_RS11890 (2414407)	2414407..2415954	-	1548	WP_000727757.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
KQY23_RS13770 (2416142)	2416142..2416213	-	72	WP_223200558.1	hypothetical protein	-
KQY23_RS11895 (2416248)	2416248..2416514	-	267	WP_000113263.1	Txe/YoeB family addiction module toxin	Toxin
KQY23_RS11900 (2416514)	2416514..2416765	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KQY23_RS11905 (2416938)	2416938..2417029	-	92	Protein_2311	hypothetical protein	-
KQY23_RS11910 (2417036)	2417036..2417635	-	600	WP_000162810.1	DsbA family protein	-
KQY23_RS11915 (2417654)	2417654..2418016	-	363	WP_000819839.1	DUF4467 domain-containing protein	-
KQY23_RS11920 (2418271)	2418271..2419521	+	1251	WP_001012236.1	FemA/FemB family glycyltransferase FmhA	-
KQY23_RS11925 (2419618)	2419618..2420349	-	732	WP_000615464.1	amino acid ABC transporter ATP-binding protein	-
KQY23_RS11930 (2420346)	2420346..2421065	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.01 Da
• Isoelectric Point: 10.1628

>T206510 WP_000113263.1 NZ_CP076823:c2416514-2416248 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T206510 NZ_CP102464:c886135-885785 [Burkholderia contaminans]
ATGGTGAGGCGCGTCAAGTTCGAGAGGGGCGATATCGTGCGCGTTAGCCTGAACCCGACCGTGGGCAAGGAGCAACAAGG
GGATTTTCGCCCCGCGCTCGTTTTGTCGCCTGCTGCGTTCAATGCGCTTGGCGTGGCGCTCGTCGCGCCGATTGCGCAGG
GCGGCGAATTCGCGCGATACGCGGGATTCGCTGTGCCCCTCTCGGGTTCGGGCACTGAAACGCAGGGCGTGGCTCTTGTG
AACATGGTTCGCACGCTCGATCTTCAGGCGCGTGGCGCACGCAAGGTCGAGCGCGCTCCGTCCGAAGTGATCGAAGATGC
GCTCGCGCGTCTTCAGACCATTCTTGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT206510 WP_000584499.1 NZ_CP076823:c2416765-2416514 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT206510 NZ_CP102464:c886380-886129 [Burkholderia contaminans]
ATGGAACTCAAAATTCAGAAGTGGGGCAACAGCGCCGCAGTCCGGCTTCCGGCCGTGTTGCTTGAGCAAATCGACGCGTC
GGTAGGTAGCTCGCTGAACGCCGATGTGCGCCCCGATGGTGTGTTGCTTTCGCCAGCCCGGCGCAAGTATTCACTGGATG
AACTGATCGCGCAGTGCGATCCGAAGGCCCCGGAACCCGCCGACCTTGCCGCGTGGGGCGAATCCAAGCCGGTGGGGCAT
GAAGCATGGTGA

Structures

Toxin

• AlphaFold DB: A0A2S6D1N9

Antitoxin

• AlphaFold DB: T1YB60