Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2416248..2416765 | Replicon | chromosome |
| Accession | NZ_CP076823 | ||
| Organism | Staphylococcus aureus strain ST59 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A2S6D1N9 |
| Locus tag | KQY23_RS11895 | Protein ID | WP_000113263.1 |
| Coordinates | 2416248..2416514 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KQY23_RS11900 | Protein ID | WP_000584499.1 |
| Coordinates | 2416514..2416765 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KQY23_RS11870 (2411508) | 2411508..2412044 | - | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
| KQY23_RS11875 (2412457) | 2412457..2413281 | - | 825 | WP_000594633.1 | formate/nitrite transporter family protein | - |
| KQY23_RS11880 (2413485) | 2413485..2413667 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| KQY23_RS11885 (2413754) | 2413754..2414221 | - | 468 | WP_000153338.1 | SRPBCC domain-containing protein | - |
| KQY23_RS11890 (2414407) | 2414407..2415954 | - | 1548 | WP_000727757.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KQY23_RS13770 (2416142) | 2416142..2416213 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| KQY23_RS11895 (2416248) | 2416248..2416514 | - | 267 | WP_000113263.1 | Txe/YoeB family addiction module toxin | Toxin |
| KQY23_RS11900 (2416514) | 2416514..2416765 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KQY23_RS11905 (2416938) | 2416938..2417029 | - | 92 | Protein_2311 | hypothetical protein | - |
| KQY23_RS11910 (2417036) | 2417036..2417635 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| KQY23_RS11915 (2417654) | 2417654..2418016 | - | 363 | WP_000819839.1 | DUF4467 domain-containing protein | - |
| KQY23_RS11920 (2418271) | 2418271..2419521 | + | 1251 | WP_001012236.1 | FemA/FemB family glycyltransferase FmhA | - |
| KQY23_RS11925 (2419618) | 2419618..2420349 | - | 732 | WP_000615464.1 | amino acid ABC transporter ATP-binding protein | - |
| KQY23_RS11930 (2420346) | 2420346..2421065 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.01 Da Isoelectric Point: 10.1628
>T206510 WP_000113263.1 NZ_CP076823:c2416514-2416248 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T206510 NZ_CP102464:c886135-885785 [Burkholderia contaminans]
ATGGTGAGGCGCGTCAAGTTCGAGAGGGGCGATATCGTGCGCGTTAGCCTGAACCCGACCGTGGGCAAGGAGCAACAAGG
GGATTTTCGCCCCGCGCTCGTTTTGTCGCCTGCTGCGTTCAATGCGCTTGGCGTGGCGCTCGTCGCGCCGATTGCGCAGG
GCGGCGAATTCGCGCGATACGCGGGATTCGCTGTGCCCCTCTCGGGTTCGGGCACTGAAACGCAGGGCGTGGCTCTTGTG
AACATGGTTCGCACGCTCGATCTTCAGGCGCGTGGCGCACGCAAGGTCGAGCGCGCTCCGTCCGAAGTGATCGAAGATGC
GCTCGCGCGTCTTCAGACCATTCTTGAATAA
ATGGTGAGGCGCGTCAAGTTCGAGAGGGGCGATATCGTGCGCGTTAGCCTGAACCCGACCGTGGGCAAGGAGCAACAAGG
GGATTTTCGCCCCGCGCTCGTTTTGTCGCCTGCTGCGTTCAATGCGCTTGGCGTGGCGCTCGTCGCGCCGATTGCGCAGG
GCGGCGAATTCGCGCGATACGCGGGATTCGCTGTGCCCCTCTCGGGTTCGGGCACTGAAACGCAGGGCGTGGCTCTTGTG
AACATGGTTCGCACGCTCGATCTTCAGGCGCGTGGCGCACGCAAGGTCGAGCGCGCTCCGTCCGAAGTGATCGAAGATGC
GCTCGCGCGTCTTCAGACCATTCTTGAATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT206510 WP_000584499.1 NZ_CP076823:c2416765-2416514 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT206510 NZ_CP102464:c886380-886129 [Burkholderia contaminans]
ATGGAACTCAAAATTCAGAAGTGGGGCAACAGCGCCGCAGTCCGGCTTCCGGCCGTGTTGCTTGAGCAAATCGACGCGTC
GGTAGGTAGCTCGCTGAACGCCGATGTGCGCCCCGATGGTGTGTTGCTTTCGCCAGCCCGGCGCAAGTATTCACTGGATG
AACTGATCGCGCAGTGCGATCCGAAGGCCCCGGAACCCGCCGACCTTGCCGCGTGGGGCGAATCCAAGCCGGTGGGGCAT
GAAGCATGGTGA
ATGGAACTCAAAATTCAGAAGTGGGGCAACAGCGCCGCAGTCCGGCTTCCGGCCGTGTTGCTTGAGCAAATCGACGCGTC
GGTAGGTAGCTCGCTGAACGCCGATGTGCGCCCCGATGGTGTGTTGCTTTCGCCAGCCCGGCGCAAGTATTCACTGGATG
AACTGATCGCGCAGTGCGATCCGAAGGCCCCGGAACCCGCCGACCTTGCCGCGTGGGGCGAATCCAAGCCGGTGGGGCAT
GAAGCATGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|