Detailed information of TA system TA206508

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2154791..2155008
• Replicon: chromosome
• Accession: NZ_CP076823
• Organism: Staphylococcus aureus strain ST59

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KQY23_RS10555
• Protein ID: WP_001802298.1
• Coordinates: 2154904..2155008 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2154791..2154846 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQY23_RS10535	2150982..2151647	-	666	WP_001024088.1	SDR family oxidoreductase	-
KQY23_RS10540	2151799..2152119	+	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KQY23_RS10545	2152121..2153098	+	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
KQY23_RS10550	2153364..2154455	+	1092	WP_000495695.1	hypothetical protein	-
-	2154791..2154846	+	56	-	-	Antitoxin
KQY23_RS10555	2154904..2155008	-	105	WP_001802298.1	hypothetical protein	Toxin
KQY23_RS10560	2155169..2155652	-	484	Protein_2049	recombinase family protein	-
KQY23_RS10565	2155695..2156831	-	1137	Protein_2050	SAP domain-containing protein	-
KQY23_RS10570	2157120..2157212	+	93	WP_031844941.1	hypothetical protein	-
KQY23_RS13765	2157499..2157713	+	215	Protein_2052	exotoxin	-
KQY23_RS10575	2157907..2158764	-	858	WP_000370919.1	HAD family hydrolase	-
KQY23_RS10580	2158832..2159614	-	783	WP_000908190.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T206508 WP_001802298.1 NZ_CP076823:c2155008-2154904 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T206508 NZ_CP102463:2833416-2833829 [Burkholderia contaminans]
ATGAGCGGGATTGACGCGACGAAATCGTTCGTCGACAGCAACGTCGTGCTTTATCTGTTGTCCGAGGACGAAACCAAGGC
GGACCGGGCAGAGTCGCTGCTGCTTCGGCGGCCGACCATCAGTGTCCAGGTGCTGAACGAGGTGGCCAGTGTCTGCAGTC
GCAAATTGCGGATGCCGTGGTTCGACGTGGGGCAATTTCTGGAGCCGATCAGGAGTTTATGCCGTGTCGTGCCGATCTCG
GTCGATACGCACGACCTGGGGCGAAAGCTGGCGGAGCGGCACGGCTTGTCCTTTTACGACGCGTGTATCGTTGCAAGCGC
TACGATCGAGGGCTGCGAATACCTCTATACCGAGGACATGCATGACGGCTTGTGCGTGGAGGGCGGGCCGGTGCTGAAAA
ATCCGTTCGCGTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT206508 NZ_CP076823:2154791-2154846 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin