Detailed information of TA system TA206502

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1847273..1847580
• Replicon: chromosome
• Accession: NZ_CP076823
• Organism: Staphylococcus aureus strain ST59

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KQY23_RS08750
• Protein ID: WP_011447039.1
• Coordinates: 1847404..1847580 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1847273..1847412 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQY23_RS08710 (1842612)	1842612..1842872	+	261	WP_001791826.1	hypothetical protein	-
KQY23_RS08715 (1842925)	1842925..1843275	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KQY23_RS08720 (1843960)	1843960..1844409	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KQY23_RS08725 (1844504)	1844504..1844839	-	336	Protein_1725	SH3 domain-containing protein	-
KQY23_RS08730 (1845489)	1845489..1845980	-	492	WP_000920037.1	staphylokinase	-
KQY23_RS08735 (1846171)	1846171..1846926	-	756	WP_000861038.1	CHAP domain-containing protein	-
KQY23_RS08740 (1846938)	1846938..1847192	-	255	WP_000611512.1	phage holin	-
KQY23_RS08745 (1847244)	1847244..1847351	+	108	WP_001791821.1	hypothetical protein	-
- (1847273)	1847273..1847412	+	140	NuclAT_0	-	Antitoxin
- (1847273)	1847273..1847412	+	140	NuclAT_0	-	Antitoxin
- (1847273)	1847273..1847412	+	140	NuclAT_0	-	Antitoxin
- (1847273)	1847273..1847412	+	140	NuclAT_0	-	Antitoxin
KQY23_RS08750 (1847404)	1847404..1847580	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KQY23_RS08755 (1847730)	1847730..1848026	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KQY23_RS08760 (1848084)	1848084..1848371	-	288	WP_001040261.1	hypothetical protein	-
KQY23_RS08765 (1848418)	1848418..1848570	-	153	WP_001153681.1	hypothetical protein	-
KQY23_RS08770 (1848560)	1848560..1852345	-	3786	WP_044557000.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	scn / chp / sak	1841590..1892950	51360

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T206502 WP_011447039.1 NZ_CP076823:c1847580-1847404 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T206502 NZ_CP102462:1982219-1982380 [Burkholderia contaminans]
GTGACCACACTCTACATGCTCGATACGAGCATCTGTTCGTTCATCATGCGCGAGCGGCCGCCCGTGGTGCTGTCCCGGTT
GCAATCGTGCGTCAATGCGCAGCACCGGATCGTCGTCTCGGCAATTACCTATGCCGAAATGCGATTCGGCGCGGCCGGCT
AG

Antitoxin

Nucleotide

• Length: 140 bp

>AT206502 NZ_CP076823:1847273-1847412 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin