Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 6876..7461 Replicon plasmid p1UC22850
Accession NZ_CP076822
Organism Acinetobacter baumannii strain UC22850

Toxin (Protein)


Gene name higB Uniprot ID N8ZPD7
Locus tag KQ255_RS20400 Protein ID WP_000897309.1
Coordinates 7141..7461 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KQ255_RS20395 Protein ID WP_000369780.1
Coordinates 6876..7148 (-) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ255_RS20365 (KQ255_20265) 2463..3167 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
KQ255_RS20370 (KQ255_20270) 3210..3341 + 132 Protein_4 helix-turn-helix domain-containing protein -
KQ255_RS20375 (KQ255_20275) 3524..4384 + 861 WP_000027057.1 broad-spectrum class A beta-lactamase TEM-1 -
KQ255_RS20380 (KQ255_20280) 4526..5344 + 819 WP_033107705.1 aminoglycoside 3-N-acetyltransferase -
KQ255_RS20385 (KQ255_20285) 5391..6095 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
KQ255_RS20390 (KQ255_20290) 6129..6290 - 162 WP_153603871.1 hypothetical protein -
KQ255_RS20395 (KQ255_20295) 6876..7148 - 273 WP_000369780.1 NadS family protein Antitoxin
KQ255_RS20400 (KQ255_20300) 7141..7461 - 321 WP_000897309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQ255_RS20405 (KQ255_20305) 7648..7845 - 198 WP_000476222.1 hypothetical protein -
KQ255_RS20410 (KQ255_20310) 7912..8139 - 228 WP_000921865.1 hypothetical protein -
KQ255_RS20415 (KQ255_20315) 8237..8452 - 216 WP_000071892.1 cold-shock protein -
KQ255_RS20420 (KQ255_20320) 8778..9209 - 432 WP_000390052.1 hypothetical protein -
KQ255_RS20425 (KQ255_20325) 9227..9493 - 267 WP_006581723.1 hypothetical protein -
KQ255_RS20430 (KQ255_20330) 9703..11139 + 1437 WP_033107832.1 MobQ family relaxase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / aac(3)-IIa - 1..11714 11714


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(41-102)

Antitoxin

(37-85)


Sequences


Toxin        


Download         Length: 107 a.a.        Molecular weight: 12209.01 Da        Isoelectric Point: 7.9835

>T206499 WP_000897309.1 NZ_CP076822:c7461-7141 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T206499 NZ_CP102459:538190-538768 [Burkholderia multivorans]
ATGAACCCCGACACGATCCGCGCACGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGTCCGGTCGCCGCGAAAGCACCGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGATGCAC
TGCCCGGCATCGACACGCTGAAGCTGCTCAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATACCG
GCGACCGAGCAAGCCGCGCATCCGGACAAGAACCTGCACGAACGCGACGACCTGCTCACGCTGACGGCCGCACTCGATCC
CGTGCTGCGTAACGAACTCGTCGCACTGTGGGACGAATACGATGCGGCCGCGTCGCCCGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATTCTGCAGCACACGCAGGGCGCCAACGCGCCCGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACGGATGCGGCACCGCTATTCAGCGCGATCCGGGCGATCGTCGATGCGGACACGCAGCGCAGGATCGA
CGCGCAAGCACGAACGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10122.63 Da        Isoelectric Point: 8.6582

>AT206499 WP_000369780.1 NZ_CP076822:c7148-6876 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT206499 NZ_CP102459:537511-538068 [Burkholderia multivorans]
ATGCCCGATTCGCCGCTTCATACGCCGCCGCTGGGCCCGCAGCTGAAACGCTGGCGCCTGCTGCATCGCGTCAAGCAAAG
CCATGCCGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCGGAACGCCTGCTCGCCGCGCGCCTCGACTCTGCGGGCGACCATGCGCTCGCGCGGCTGGTCGCAGCG
AGCGCGGGCCGCATGCATCTCGTCTGCGATCTGACGCACCGGCTGCTTGCATGCTCGCCGTCTCGCGCAGCCGAGTTCTC
GCAGCCGCTGCCGATGCTGCTCGGCACGTCGCTCTGGCGCTATGCGACAGAAGAAATCGTCCGGATGGAAACCGCACTGG
ACACACTCGGCTGGCACGACTGCGCAGGACCGCCGAGCGTCGAATTCGACACCGGCACGAACGCATCGCGCGTCGTGCCG
ATCCATCGCAGCCGATGCCGCTGGACGCGGATCATGCTGTCGGACGGGTCGGCGGCACGGCTCGTCGAAACGCTGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A855WJQ3


Antitoxin

Source ID Structure

References