Detailed information of TA system TA206496

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 53474..54132
• Replicon: plasmid p1UC24137
• Accession: NZ_CP076818
• Organism: Acinetobacter baumannii strain UC24137

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KQ257_RS19370
• Protein ID: WP_000312250.1
• Coordinates: 53773..54132 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KQ257_RS19365
• Protein ID: WP_001096429.1
• Coordinates: 53474..53773 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ257_RS19335 (KQ257_19260)	48554..48817	+	264	Protein_55	ATP-binding protein	-
KQ257_RS19340 (KQ257_19265)	48922..49743	-	822	WP_001046004.1	OXA-23 family carbapenem-hydrolyzing class D beta-lactamase OXA-23	-
KQ257_RS19345 (KQ257_19270)	49842..50524	+	683	Protein_57	IS4-like element ISAba1 family transposase	-
KQ257_RS19350 (KQ257_19275)	50578..51510	-	933	WP_080631276.1	IS5-like element IS17 family transposase	-
KQ257_RS19355 (KQ257_19280)	51797..52351	+	555	WP_000790082.1	hypothetical protein	-
KQ257_RS19360 (KQ257_19285)	52401..52937	+	537	WP_000732006.1	hypothetical protein	-
KQ257_RS19365 (KQ257_19290)	53474..53773	-	300	WP_001096429.1	XRE family transcriptional regulator	Antitoxin
KQ257_RS19370 (KQ257_19295)	53773..54132	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQ257_RS19375 (KQ257_19300)	54333..54899	+	567	WP_046693259.1	hypothetical protein	-
KQ257_RS19380 (KQ257_19305)	54948..55130	+	183	WP_000373385.1	hypothetical protein	-
KQ257_RS19385 (KQ257_19310)	55197..55895	+	699	WP_000873188.1	hypothetical protein	-
KQ257_RS19390 (KQ257_19315)	56034..56417	+	384	WP_000654348.1	hypothetical protein	-
KQ257_RS19395 (KQ257_19320)	56484..57242	+	759	WP_001053128.1	hypothetical protein	-
KQ257_RS19400 (KQ257_19325)	57294..57629	+	336	WP_000653925.1	hypothetical protein	-
KQ257_RS19405 (KQ257_19330)	58496..58810	+	315	WP_000708715.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	ant(2'')-Ia / floR / sul2 / blaOXA-23	-	1..99399	99399

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T206496 WP_000312250.1 NZ_CP076818:c54132-53773 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T206496 NZ_CP102458:c2594959-2594651 [Burkholderia multivorans]
ATGAACACGATCAACCAAACAGGCGAGTTCCAGGAGTGGCTCCGCGACCTGAAAGATAAGGTTGGAAGGGGCGCCATCCT
TGGCCGAATCAATCGTGCGCGCTTGGGGAATTTCGGCGATCACAAAGATTTGGGCGATGGTGTTTCAGAGATGCGGATTG
ATGTCGGACCAGGATACCGCGTCTACTTCGGCCGCGATGGCAAGGACATCTACTTGCTCATTTGCGGGGGTGACAAATCC
TCTCAGGACAAGGATATCAAGCACGCCAAGGCGATCTGGGAGCAGTTCAGGAAGGAGCAACAGCCATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT206496 WP_001096429.1 NZ_CP076818:c53773-53474 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT206496 NZ_CP102458:c2594654-2594349 [Burkholderia multivorans]
ATGACCACAACCGAAGCGATCAAAGTGACGCCCTTTGATGCATCGGAATACCTTGACGACGAAGAAACAATCGCGAGCTA
TATCAGTGCTGCGATGGAAGCAGACGACCAAGATGTTCTTCTTCTGGCTCTCGCTGACGTCGCAAAGGCCAGAGGCATGG
CTAAGGTAGCAGCCGATGCTGGATTGGGCCGGGAAAGCCTTTACAAGGCCCTCAAGCCAGGTGCGAATCCAAAATACGAG
ACCGTCAACAAATTGATGCATGCCCTTGGGATCAAGTTCGCCGCGGTTCCGAATCGAAAGAGTTGA