206491

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4524..5109 Replicon plasmid p2UC21460
Accession NZ_CP076816
Organism Acinetobacter baumannii strain UC21460

Toxin (Protein)


Gene name higB Uniprot ID N8ZPD7
Locus tag KQ256_RS19045 Protein ID WP_000897309.1
Coordinates 4524..4844 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A009MRQ1
Locus tag KQ256_RS19050 Protein ID WP_032001914.1
Coordinates 4837..5109 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ256_RS19010 (KQ256_19000) 1..924 + 924 WP_033107831.1 replication initiation protein RepM -
KQ256_RS19015 (KQ256_19005) 1009..1542 + 534 WP_033107830.1 plasmid replication DNA-binding protein -
KQ256_RS19020 (KQ256_19010) 1829..2356 + 528 WP_000537572.1 plasmid pRiA4b ORF-3 family protein -
KQ256_RS19025 (KQ256_19015) 2537..3148 + 612 WP_008942536.1 recombinase family protein -
KQ256_RS19030 (KQ256_19020) 3533..3748 + 216 WP_000071892.1 cold-shock protein -
KQ256_RS19035 (KQ256_19025) 3846..4073 + 228 WP_000921865.1 hypothetical protein -
KQ256_RS19040 (KQ256_19030) 4140..4337 + 198 WP_000476222.1 hypothetical protein -
KQ256_RS19045 (KQ256_19035) 4524..4844 + 321 WP_000897309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQ256_RS19050 (KQ256_19040) 4837..5109 + 273 WP_032001914.1 NadS family protein Antitoxin
KQ256_RS19055 (KQ256_19045) 5583..6188 - 606 WP_000447788.1 LysE family translocator -
KQ256_RS19060 (KQ256_19050) 6238..7065 - 828 WP_000073658.1 AraC family transcriptional regulator -
KQ256_RS19065 (KQ256_19055) 7239..7945 - 707 Protein_11 IS1 family transposase -
KQ256_RS19070 (KQ256_19060) 8036..8878 - 843 WP_002002480.1 carbapenem-hydrolyzing class D beta-lactamase OXA-58 -
KQ256_RS19075 (KQ256_19065) 9083..9787 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
KQ256_RS19080 (KQ256_19070) 9821..9982 - 162 WP_153603871.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 - 1..17469 17469


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12209.01 Da        Isoelectric Point: 7.9835

>T206491 WP_000897309.1 NZ_CP076816:4524-4844 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Download         Length: 321 bp

>T206491 NZ_CP102441:c4767790-4767203 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGTTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10088.61 Da        Isoelectric Point: 8.6582

>AT206491 WP_032001914.1 NZ_CP076816:4837-5109 [Acinetobacter baumannii]
MDNNLLDDLVASIKEAGAIKRKEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Download         Length: 273 bp

>AT206491 NZ_CP102441:c4767136-4766282 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGTGTGCCGCGCTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGGTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGTGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGCGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCATCCTTGACGATCTACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855WJQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A009MRQ1

References