Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 45800..46458 Replicon plasmid p1UC24371
Accession NZ_CP076805
Organism Acinetobacter baumannii strain UC24371

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KQ251_RS19430 Protein ID WP_000312250.1
Coordinates 46099..46458 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KQ251_RS19425 Protein ID WP_001096429.1
Coordinates 45800..46099 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ251_RS19390 (KQ251_19320) 40965..41594 + 630 WP_000701002.1 hypothetical protein -
KQ251_RS19395 (KQ251_19325) 41634..42143 + 510 WP_001043200.1 hypothetical protein -
KQ251_RS19400 (KQ251_19330) 42225..42737 + 513 WP_000840065.1 hypothetical protein -
KQ251_RS19405 (KQ251_19335) 42793..43122 + 330 WP_227505947.1 hypothetical protein -
KQ251_RS19410 (KQ251_19340) 43159..43887 + 729 WP_001022819.1 hypothetical protein -
KQ251_RS19415 (KQ251_19345) 44123..44677 + 555 WP_000790082.1 hypothetical protein -
KQ251_RS19420 (KQ251_19350) 44727..45263 + 537 WP_000732006.1 hypothetical protein -
KQ251_RS19425 (KQ251_19355) 45800..46099 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
KQ251_RS19430 (KQ251_19360) 46099..46458 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQ251_RS19435 (KQ251_19365) 46659..47225 + 567 WP_046693259.1 hypothetical protein -
KQ251_RS19440 (KQ251_19370) 47274..47456 + 183 WP_000373385.1 hypothetical protein -
KQ251_RS19445 (KQ251_19375) 47523..48221 + 699 WP_000873188.1 hypothetical protein -
KQ251_RS19450 (KQ251_19380) 48360..48743 + 384 WP_000654348.1 hypothetical protein -
KQ251_RS19455 (KQ251_19385) 48810..49568 + 759 WP_001053128.1 hypothetical protein -
KQ251_RS19460 (KQ251_19390) 49620..49955 + 336 WP_000653925.1 hypothetical protein -
KQ251_RS19465 (KQ251_19395) 50822..51136 + 315 WP_000708715.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-23 - 1..105056 105056


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T206481 WP_000312250.1 NZ_CP076805:c46458-46099 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T206481 NZ_CP102439:c111830-111348 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT206481 WP_001096429.1 NZ_CP076805:c46099-45800 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT206481 NZ_CP102439:c112084-111818 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References