Detailed information of TA system TA206461

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2774915..2775504
• Replicon: chromosome
• Accession: NZ_CP076726
• Organism: Xanthomonas arboricola pv. juglandis strain IVIA 2499

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A2N7V9W3
• Locus tag: KP728_RS12095
• Protein ID: WP_016902142.1
• Coordinates: 2775223..2775504 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: KP728_RS12090
• Protein ID: WP_026064232.1
• Coordinates: 2774915..2775205 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP728_RS12060 (KP728_12005)	2770556..2771293	-	738	WP_231103951.1	RNA polymerase sigma factor	-
KP728_RS12065 (KP728_12010)	2771286..2771708	-	423	WP_080639762.1	SymE family type I addiction module toxin	-
KP728_RS12070 (KP728_12015)	2772319..2772540	+	222	WP_053046120.1	hypothetical protein	-
KP728_RS12080 (KP728_12025)	2774040..2774372	+	333	WP_026064233.1	hypothetical protein	-
KP728_RS12085	2774522..2774724	+	203	Protein_2363	hypothetical protein	-
KP728_RS12090 (KP728_12030)	2774915..2775205	-	291	WP_026064232.1	HigA family addiction module antitoxin	Antitoxin
KP728_RS12095 (KP728_12035)	2775223..2775504	-	282	WP_016902142.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KP728_RS12100 (KP728_12040)	2775644..2777770	-	2127	WP_039816188.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11064.75 Da
• Isoelectric Point: 9.7972

>T206461 WP_016902142.1 NZ_CP076726:c2775504-2775223 [Xanthomonas arboricola pv. juglandis]
MIRSFVDKEAEKIWMGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Nucleotide

• Length: 282 bp

>T206461 NZ_CP102435:c4441073-4440726 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10555.21 Da
• Isoelectric Point: 8.7586

>AT206461 WP_026064232.1 NZ_CP076726:c2775205-2774915 [Xanthomonas arboricola pv. juglandis]
MTVLPNIHPGEILREEFLEPMGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLSLQADYELEQA
HRALGDLPSRIKRLAA

Nucleotide

• Length: 291 bp

>AT206461 NZ_CP102435:c4440726-4440427 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: A0A2N7V9W3