206458

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 108546..109135 Replicon chromosome
Accession NZ_CP076725
Organism Xanthomonas arboricola pv. juglandis strain IVIA 1317

Toxin (Protein)


Gene name graT Uniprot ID A0A2N7V9W3
Locus tag KP727_RS00425 Protein ID WP_016902142.1
Coordinates 108546..108827 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag KP727_RS00430 Protein ID WP_026064232.1
Coordinates 108845..109135 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP727_RS00420 (KP727_00410) 106280..108406 + 2127 WP_039816188.1 exodeoxyribonuclease V subunit alpha -
KP727_RS00425 (KP727_00415) 108546..108827 + 282 WP_016902142.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KP727_RS00430 (KP727_00420) 108845..109135 + 291 WP_026064232.1 HigA family addiction module antitoxin Antitoxin
KP727_RS00435 109326..109528 - 203 Protein_85 hypothetical protein -
KP727_RS00440 (KP727_00425) 109678..110010 - 333 WP_026064233.1 hypothetical protein -
KP727_RS00445 (KP727_00430) 110135..111237 + 1103 WP_102596355.1 IS3-like element IS1403 family transposase -
KP727_RS00450 (KP727_00435) 111510..111731 - 222 WP_053046120.1 hypothetical protein -
KP727_RS00455 (KP727_00440) 112342..112764 + 423 WP_080639762.1 SymE family type I addiction module toxin -
KP727_RS00460 (KP727_00445) 112757..113494 + 738 WP_231103951.1 RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11064.75 Da        Isoelectric Point: 9.7972

>T206458 WP_016902142.1 NZ_CP076725:108546-108827 [Xanthomonas arboricola pv. juglandis]
MIRSFVDKEAEKIWMGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Download         Length: 282 bp

>T206458 NZ_CP102435:c2820803-2820701 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10555.21 Da        Isoelectric Point: 8.7586

>AT206458 WP_026064232.1 NZ_CP076725:108845-109135 [Xanthomonas arboricola pv. juglandis]
MTVLPNIHPGEILREEFLEPMGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLSLQADYELEQA
HRALGDLPSRIKRLAA

Download         Length: 291 bp

>AT206458 NZ_CP102435:2820694-2820839 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N7V9W3

Antitoxin

Source ID Structure

References