Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3520476..3520734 Replicon chromosome
Accession NZ_CP076706
Organism Escherichia coli O170:H18 strain CFIAFB20120266

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag KQ217_RS17080 Protein ID WP_000809168.1
Coordinates 3520476..3520628 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3520677..3520734 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ217_RS17060 3515721..3516434 - 714 WP_001102393.1 acidic protein MsyB -
KQ217_RS17065 3516460..3516864 - 405 WP_000843687.1 DUF2541 family protein -
KQ217_RS17070 3517236..3519152 + 1917 WP_000516135.1 molecular chaperone DnaK -
KQ217_RS17075 3519241..3520371 + 1131 WP_001118464.1 molecular chaperone DnaJ -
KQ217_RS17080 3520476..3520628 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3520677..3520734 + 58 - - Antitoxin
KQ217_RS17085 3521243..3522004 + 762 WP_001274832.1 outer membrane protein OmpK -
KQ217_RS17090 3522024..3523517 + 1494 WP_001350365.1 sulfatase-like hydrolase/transferase -
KQ217_RS17095 3523646..3524905 + 1260 WP_000494924.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T206402 WP_000809168.1 NZ_CP076706:c3520628-3520476 [Escherichia coli O170:H18]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T206402 NZ_CP102380:c1142913-1142806 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 58 bp

>AT206402 NZ_CP076706:3520677-3520734 [Escherichia coli O170:H18]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References