Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 99218..99644 | Replicon | plasmid unnamed |
| Accession | NZ_CP076705 | ||
| Organism | Escherichia coli O8:H28 strain BMH-17-0027 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | KQ221_RS23635 | Protein ID | WP_001372321.1 |
| Coordinates | 99218..99343 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 99420..99644 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KQ221_RS23605 (94260) | 94260..94487 | - | 228 | WP_032142519.1 | conjugal transfer relaxosome protein TraY | - |
| KQ221_RS23610 (94575) | 94575..95264 | - | 690 | WP_000332473.1 | PAS domain-containing protein | - |
| KQ221_RS23615 (95457) | 95457..95840 | - | 384 | WP_001151560.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| KQ221_RS23620 (96125) | 96125..96772 | + | 648 | WP_123006995.1 | transglycosylase SLT domain-containing protein | - |
| KQ221_RS23625 (97069) | 97069..97890 | - | 822 | WP_001234469.1 | DUF932 domain-containing protein | - |
| KQ221_RS23630 (98009) | 98009..98296 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| KQ221_RS23950 (98321) | 98321..98527 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| KQ221_RS23955 (98597) | 98597..98770 | + | 174 | Protein_100 | hypothetical protein | - |
| KQ221_RS23960 (98768) | 98768..98998 | - | 231 | WP_074014914.1 | hypothetical protein | - |
| KQ221_RS23635 (99218) | 99218..99343 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| KQ221_RS23965 (99285) | 99285..99434 | - | 150 | Protein_103 | plasmid maintenance protein Mok | - |
| - (99420) | 99420..99644 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (99420) | 99420..99644 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (99420) | 99420..99644 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (99420) | 99420..99644 | - | 225 | NuclAT_0 | - | Antitoxin |
| KQ221_RS23640 (99456) | 99456..99644 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| KQ221_RS23645 (99613) | 99613..100375 | - | 763 | Protein_105 | plasmid SOS inhibition protein A | - |
| KQ221_RS23650 (100372) | 100372..100806 | - | 435 | WP_021572430.1 | conjugation system SOS inhibitor PsiB | - |
| KQ221_RS23655 (100860) | 100860..102818 | - | 1959 | Protein_107 | ParB/RepB/Spo0J family partition protein | - |
| KQ221_RS23660 (102884) | 102884..103117 | - | 234 | WP_097446487.1 | DUF905 family protein | - |
| KQ221_RS23665 (103180) | 103180..103719 | - | 540 | WP_097446486.1 | single-stranded DNA-binding protein | - |
| KQ221_RS23670 (103745) | 103745..103951 | - | 207 | WP_000275853.1 | hypothetical protein | - |
| KQ221_RS23675 (103864) | 103864..104199 | - | 336 | WP_175085812.1 | hypothetical protein | - |
| KQ221_RS23970 (104192) | 104192..104443 | - | 252 | WP_097446485.1 | hypothetical protein | - |
| KQ221_RS23975 (104362) | 104362..104598 | - | 237 | WP_244585276.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | hlyD / hlyB / hlyA / hlyC | 1..117710 | 117710 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T206376 WP_001372321.1 NZ_CP076705:c99343-99218 [Escherichia coli O8:H28]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T206376 NZ_CP102379:c246234-245956 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 225 bp
>AT206376 NZ_CP076705:c99644-99420 [Escherichia coli O8:H28]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
