20637

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1645045..1645557 Replicon chromosome
Accession NC_003028
Organism Streptococcus pneumoniae TIGR4

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag SP_RS08610 Protein ID WP_000924721.1
Coordinates 1645045..1645299 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag SP_RS08615 Protein ID WP_000388572.1
Coordinates 1645303..1645557 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SP_RS08595 (SP_1737) 1642146..1642460 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
SP_RS08600 (SP_1738) 1642485..1643111 - 627 WP_000775037.1 guanylate kinase -
SP_RS08605 (SP_1739) 1643241..1644854 - 1614 WP_000404940.1 ribonuclease Y -
SP_RS08610 (SP_1740) 1645045..1645299 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
SP_RS08615 (SP_1741) 1645303..1645557 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SP_RS08620 (SP_1742) 1645795..1646892 - 1098 WP_000156358.1 nucleotidyltransferase -
SP_RS08625 (SP_1743) 1646902..1647648 - 747 WP_000605157.1 class I SAM-dependent methyltransferase -
SP_RS08630 (SP_1744) 1647751..1648104 - 354 WP_001003023.1 ribosome silencing factor -
SP_RS08635 (SP_1745) 1648117..1648617 - 501 WP_000844707.1 cysteine hydrolase -
SP_RS08640 (SP_1746) 1648618..1649211 - 594 WP_000121667.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
SP_RS08645 (SP_1747) 1649211..1649840 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
SP_RS08650 (SP_1748) 1649892..1650203 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T20637 WP_000924721.1 NC_003028:c1645299-1645045 [Streptococcus pneumoniae TIGR4]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T20637 NC_003028:c1645299-1645045 [Streptococcus pneumoniae TIGR4]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT20637 WP_000388572.1 NC_003028:c1645557-1645303 [Streptococcus pneumoniae TIGR4]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT20637 NC_003028:c1645557-1645303 [Streptococcus pneumoniae TIGR4]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References