Detailed information of TA system TA206343

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2344379..2344968
• Replicon: chromosome
• Accession: NZ_CP076701
• Organism: Xanthomonas arboricola pv. pruni strain CITA 33

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A2S7AZR2
• Locus tag: KQR53_RS10200
• Protein ID: WP_039429225.1
• Coordinates: 2344379..2344660 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KQR53_RS10205
• Protein ID: WP_006449989.1
• Coordinates: 2344678..2344968 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQR53_RS10195 (KQR53_10145)	2342113..2344239	+	2127	WP_043087609.1	exodeoxyribonuclease V subunit alpha	-
KQR53_RS10200 (KQR53_10150)	2344379..2344660	+	282	WP_039429225.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQR53_RS10205 (KQR53_10155)	2344678..2344968	+	291	WP_006449989.1	HigA family addiction module antitoxin	Antitoxin
KQR53_RS10210	2345159..2345361	-	203	Protein_1995	hypothetical protein	-
KQR53_RS10215 (KQR53_10160)	2345511..2345843	-	333	WP_039513672.1	lipoprotein	-
KQR53_RS10220 (KQR53_10165)	2346017..2347915	-	1899	WP_126750750.1	hypothetical protein	-
KQR53_RS10225 (KQR53_10170)	2347990..2348826	-	837	WP_081327584.1	restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-82)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11046.72 Da
• Isoelectric Point: 9.7972

>T206343 WP_039429225.1 NZ_CP076701:2344379-2344660 [Xanthomonas arboricola pv. pruni]
MIRSFVDKEAEKIWLGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Nucleotide

• Length: 282 bp

>T206343 NZ_CP102374:3968634-3969062 [Pseudomonas sp. T8]
ATGATAGTACTCGACACAAATGTGTTGTCAGAACTGATGCGCCCTCAACCGGATACGGCGGTATTGCTGTGGATCGAAGC
GCAACCCGTCGAAGACCTCTACATCAGCGCCATGACCATGGCCGAGATTCTCCACGGTATCGCGCGCCTGCCCCACGGCA
AGCGCAAACAGACGCTGCATGCATCGGCGCTGGCTATGTTCGAGGAAGACTTCATCGACCGCATCGTGCCCTTCGGAACC
CAAGCGGCTCTTTACTACGCGCATCTGGTCTCGCATCGCGAAAGATCAGGCCAGCCGATCAATCTGGTGGATGCGCAAAT
TGCAGCGATATGCCGGGTCCACGACGCCGCGATCGCCACTCGTAACACCAAGGATTTCACCGACACCGGGCTGATCGTTA
TCAACCCCTGGCTGCCGCTCGAGGTCTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10540.20 Da
• Isoelectric Point: 6.4664

>AT206343 WP_006449989.1 NZ_CP076701:2344678-2344968 [Xanthomonas arboricola pv. pruni]
MTVLPNIHPGEILLEEFLEPMGISQNALARATDVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Nucleotide

• Length: 291 bp

>AT206343 NZ_CP102374:3968392-3968637 [Pseudomonas sp. T8]
ATGGCCAGCCTTACGATCCGTAATCTGGACGACCACATCAAAGAACGCCTGCGCATCGAGGCCGCTCACAATGGTCATTC
CATGGAAGAAGAAGCCCGATTGATTTTGCGCCGCGCATTGAGCAGGACAGCTGACAGCCAAGGCCTGGGCAGCCGTATCA
GGGCACGCTTTGCCGAGACCGGCGGAGTAGAGCTGGAGCTGCCTGAACGTACCGAACCGGCACGCTTGGTGGACCTGGGC
GAATGA

Structures

Toxin

• AlphaFold DB: A0A2S7AZR2