206332

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4398270..4398872 Replicon chromosome
Accession NZ_CP076697
Organism Escherichia coli strain S10EC

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag KQ259_RS21420 Protein ID WP_000897302.1
Coordinates 4398270..4398581 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KQ259_RS21425 Protein ID WP_000356397.1
Coordinates 4398582..4398872 (+) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ259_RS21395 (4394184) 4394184..4394783 + 600 WP_001296610.1 glucose-1-phosphatase -
KQ259_RS21400 (4394777) 4394777..4395649 + 873 WP_000920762.1 virulence factor BrkB family protein -
KQ259_RS21405 (4395646) 4395646..4396083 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
KQ259_RS21410 (4396128) 4396128..4397069 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
KQ259_RS21415 (4397133) 4397133..4398041 - 909 WP_001385591.1 alpha/beta hydrolase -
KQ259_RS21420 (4398270) 4398270..4398581 + 312 WP_000897302.1 hypothetical protein Toxin
KQ259_RS21425 (4398582) 4398582..4398872 + 291 WP_000356397.1 NadS family protein Antitoxin
KQ259_RS21430 (4399231) 4399231..4399509 + 279 WP_001296612.1 hypothetical protein -
KQ259_RS21435 (4399906) 4399906..4400124 + 219 WP_001251293.1 CopG family transcriptional regulator -
KQ259_RS25545 (4400309) 4400309..4401049 - 741 WP_000608806.1 hypothetical protein -
KQ259_RS21445 (4401074) 4401074..4401922 - 849 WP_001038650.1 hypothetical protein -
KQ259_RS21450 (4402212) 4402212..4402454 + 243 WP_001068514.1 CopG family transcriptional regulator -
KQ259_RS21455 (4402636) 4402636..4403565 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(36-85)


Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T206332 WP_000897302.1 NZ_CP076697:4398270-4398581 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T206332 NZ_CP102358:5918492-5918788 [Pseudomonas zeae]
ATGACCTATAACCTTGAATTTGATCGTCGTGCTTTAAAGGAGTGGAACAAACTCGGCGATACGGTTCGCCACCAGTTCAA
GAAGAAGCTCACAGAGGTATTGGAGAATCCTCGAATAGAAGCCAATCGACTTCGCGAGCTCCCGGATTGCTACAAAGTGA
AGCTGAAAAGCGCTGGCTATCGCCTGATCTATCAGGTCCTTGATCAAGAGATTGTGGTGTTTGTAATCGCAATCGGGAAG
CGAGAGAGAGAAGCTGCTTACGAGGTTGCGCAGGACCGTCTTTCGCTCCTGCCCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT206332 WP_000356397.1 NZ_CP076697:4398582-4398872 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT206332 NZ_CP102358:5918263-5918502 [Pseudomonas zeae]
ATGGCCTCCATCAACATTCGCATCGACGATGATCTGAAGCAGCGCTCCTTCGCCGAACTGGAAAAGCTGGGAGTAACTCC
CTCAGAGCTTTTGCGTCAGACACTCCAATACGTCGCCGAGCGAGGCAAGCTACCCTTCAAAGCAGCATTGCTCAGCGAGG
AAGATGAAGTACTCATAGCCGTAGTCACCGAACGCCTCGCGGCACCTCAACGAGTCAAGGTAAGTCTGGATGACCTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1P416


Antitoxin

Source ID Structure

References