Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 4398270..4398872 | Replicon | chromosome |
Accession | NZ_CP076697 | ||
Organism | Escherichia coli strain S10EC |
Toxin (Protein)
Gene name | higB | Uniprot ID | S1P416 |
Locus tag | KQ259_RS21420 | Protein ID | WP_000897302.1 |
Coordinates | 4398270..4398581 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | KQ259_RS21425 | Protein ID | WP_000356397.1 |
Coordinates | 4398582..4398872 (+) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KQ259_RS21395 (4394184) | 4394184..4394783 | + | 600 | WP_001296610.1 | glucose-1-phosphatase | - |
KQ259_RS21400 (4394777) | 4394777..4395649 | + | 873 | WP_000920762.1 | virulence factor BrkB family protein | - |
KQ259_RS21405 (4395646) | 4395646..4396083 | + | 438 | WP_000560981.1 | D-aminoacyl-tRNA deacylase | - |
KQ259_RS21410 (4396128) | 4396128..4397069 | + | 942 | WP_001297068.1 | fatty acid biosynthesis protein FabY | - |
KQ259_RS21415 (4397133) | 4397133..4398041 | - | 909 | WP_001385591.1 | alpha/beta hydrolase | - |
KQ259_RS21420 (4398270) | 4398270..4398581 | + | 312 | WP_000897302.1 | hypothetical protein | Toxin |
KQ259_RS21425 (4398582) | 4398582..4398872 | + | 291 | WP_000356397.1 | NadS family protein | Antitoxin |
KQ259_RS21430 (4399231) | 4399231..4399509 | + | 279 | WP_001296612.1 | hypothetical protein | - |
KQ259_RS21435 (4399906) | 4399906..4400124 | + | 219 | WP_001251293.1 | CopG family transcriptional regulator | - |
KQ259_RS25545 (4400309) | 4400309..4401049 | - | 741 | WP_000608806.1 | hypothetical protein | - |
KQ259_RS21445 (4401074) | 4401074..4401922 | - | 849 | WP_001038650.1 | hypothetical protein | - |
KQ259_RS21450 (4402212) | 4402212..4402454 | + | 243 | WP_001068514.1 | CopG family transcriptional regulator | - |
KQ259_RS21455 (4402636) | 4402636..4403565 | - | 930 | WP_000027696.1 | formate dehydrogenase accessory protein FdhE | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12203.19 Da Isoelectric Point: 9.7791
>T206332 WP_000897302.1 NZ_CP076697:4398270-4398581 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T206332 NZ_CP102358:5918492-5918788 [Pseudomonas zeae]
ATGACCTATAACCTTGAATTTGATCGTCGTGCTTTAAAGGAGTGGAACAAACTCGGCGATACGGTTCGCCACCAGTTCAA
GAAGAAGCTCACAGAGGTATTGGAGAATCCTCGAATAGAAGCCAATCGACTTCGCGAGCTCCCGGATTGCTACAAAGTGA
AGCTGAAAAGCGCTGGCTATCGCCTGATCTATCAGGTCCTTGATCAAGAGATTGTGGTGTTTGTAATCGCAATCGGGAAG
CGAGAGAGAGAAGCTGCTTACGAGGTTGCGCAGGACCGTCTTTCGCTCCTGCCCTGA
ATGACCTATAACCTTGAATTTGATCGTCGTGCTTTAAAGGAGTGGAACAAACTCGGCGATACGGTTCGCCACCAGTTCAA
GAAGAAGCTCACAGAGGTATTGGAGAATCCTCGAATAGAAGCCAATCGACTTCGCGAGCTCCCGGATTGCTACAAAGTGA
AGCTGAAAAGCGCTGGCTATCGCCTGATCTATCAGGTCCTTGATCAAGAGATTGTGGTGTTTGTAATCGCAATCGGGAAG
CGAGAGAGAGAAGCTGCTTACGAGGTTGCGCAGGACCGTCTTTCGCTCCTGCCCTGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10846.43 Da Isoelectric Point: 10.8907
>AT206332 WP_000356397.1 NZ_CP076697:4398582-4398872 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT206332 NZ_CP102358:5918263-5918502 [Pseudomonas zeae]
ATGGCCTCCATCAACATTCGCATCGACGATGATCTGAAGCAGCGCTCCTTCGCCGAACTGGAAAAGCTGGGAGTAACTCC
CTCAGAGCTTTTGCGTCAGACACTCCAATACGTCGCCGAGCGAGGCAAGCTACCCTTCAAAGCAGCATTGCTCAGCGAGG
AAGATGAAGTACTCATAGCCGTAGTCACCGAACGCCTCGCGGCACCTCAACGAGTCAAGGTAAGTCTGGATGACCTATAA
ATGGCCTCCATCAACATTCGCATCGACGATGATCTGAAGCAGCGCTCCTTCGCCGAACTGGAAAAGCTGGGAGTAACTCC
CTCAGAGCTTTTGCGTCAGACACTCCAATACGTCGCCGAGCGAGGCAAGCTACCCTTCAAAGCAGCATTGCTCAGCGAGG
AAGATGAAGTACTCATAGCCGTAGTCACCGAACGCCTCGCGGCACCTCAACGAGTCAAGGTAAGTCTGGATGACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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