Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
Location | 3527797..3528596 | Replicon | chromosome |
Accession | NZ_CP076697 | ||
Organism | Escherichia coli strain S10EC |
Toxin (Protein)
Gene name | yhaV | Uniprot ID | S1NYM6 |
Locus tag | KQ259_RS17195 | Protein ID | WP_000347251.1 |
Coordinates | 3528132..3528596 (+) | Length | 155 a.a. |
Antitoxin (Protein)
Gene name | prlF | Uniprot ID | S1PPV5 |
Locus tag | KQ259_RS17190 | Protein ID | WP_001296435.1 |
Coordinates | 3527797..3528132 (+) | Length | 112 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KQ259_RS17175 (3523582) | 3523582..3524352 | - | 771 | WP_001058227.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
KQ259_RS17180 (3524368) | 3524368..3525702 | - | 1335 | WP_000599651.1 | galactarate/glucarate/glycerate transporter GarP | - |
KQ259_RS17185 (3526077) | 3526077..3527648 | + | 1572 | WP_001273763.1 | galactarate dehydratase | - |
KQ259_RS17190 (3527797) | 3527797..3528132 | + | 336 | WP_001296435.1 | type II toxin-antitoxin system antitoxin PrlF | Antitoxin |
KQ259_RS17195 (3528132) | 3528132..3528596 | + | 465 | WP_000347251.1 | type II toxin-antitoxin system ribonuclease toxin YhaV | Toxin |
KQ259_RS17200 (3528651) | 3528651..3529460 | - | 810 | WP_000072187.1 | aga operon transcriptional regulator AgaR | - |
KQ259_RS17205 (3529709) | 3529709..3530989 | + | 1281 | WP_000681950.1 | tagatose-bisphosphate aldolase subunit KbaZ | - |
KQ259_RS17210 (3531012) | 3531012..3531485 | + | 474 | WP_001295547.1 | PTS N-acetylgalactosamine transporter subunit IIB | - |
KQ259_RS17215 (3531496) | 3531496..3532275 | + | 780 | WP_000406214.1 | PTS N-acetylgalactosamine transporter subunit IIC | - |
KQ259_RS17220 (3532265) | 3532265..3533143 | + | 879 | WP_001295548.1 | PTS N-acetylgalactosamine transporter subunit IID | - |
KQ259_RS17225 (3533161) | 3533161..3533595 | + | 435 | WP_000948824.1 | PTS galactosamine/N-acetylgalactosamine transporter subunit IIA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17777.14 Da Isoelectric Point: 9.4947
>T206329 WP_000347251.1 NZ_CP076697:3528132-3528596 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH
Download Length: 465 bp
>T206329 NZ_CP102358:2063143-2063355 [Pseudomonas zeae]
GTGCAAAGCAGGTTATTGATCAAGGAGCTGGAGGAGGCGGGTTGGACGCTGGACCGGATTACCGGCAGTCATCACATTTT
CAGGCACCGTTACAACCCTTACACGATTCCCGTTCCTCATCCGAAAAAGGATTTGCCGTTGGGGACAGTCAAAAGCATCA
GGAGACGTGCCGGGTTGTACAACCCGCCAGCCAGTTTCGAAGGAGATCCATAA
GTGCAAAGCAGGTTATTGATCAAGGAGCTGGAGGAGGCGGGTTGGACGCTGGACCGGATTACCGGCAGTCATCACATTTT
CAGGCACCGTTACAACCCTTACACGATTCCCGTTCCTCATCCGAAAAAGGATTTGCCGTTGGGGACAGTCAAAAGCATCA
GGAGACGTGCCGGGTTGTACAACCCGCCAGCCAGTTTCGAAGGAGATCCATAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12321.92 Da Isoelectric Point: 4.5392
>AT206329 WP_001296435.1 NZ_CP076697:3527797-3528132 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE
Download Length: 336 bp
>AT206329 NZ_CP102358:2063355-2063759 [Pseudomonas zeae]
ATGCAATATCCAATCTGTATCGAGTGGGGAGACGAGAACACTGCCATCGGTATTCAGATCCCCGATATTCCCGGCGCCGT
TACAGCGGGGGATAGCTTTGAAGATGCCTACAACGCGGCGGTTGAAGTCGCCCACATCATGCTGCAGGAGATTGCGGCGG
ACGGGGAGTCGATTCCTATGCCGACTTCGGCATCCGCTCATCGCAGTAATCCGGACTTTGCCGACATGGGTTGGGGCATG
CTCGAGCTGGATATTTCGCCTTATCTCGGCAAGACCGAAAAGGTCAACGTGACGTTGCCTGGCTATGTAATTCAGCGCAT
CGATCGTTATGTGCGCGAACACAACGTCAAAAGCCGTTCCTCCTTTCTGGCGGATGCGGCGATGGAGAAACTGGTTCGTT
ACTAA
ATGCAATATCCAATCTGTATCGAGTGGGGAGACGAGAACACTGCCATCGGTATTCAGATCCCCGATATTCCCGGCGCCGT
TACAGCGGGGGATAGCTTTGAAGATGCCTACAACGCGGCGGTTGAAGTCGCCCACATCATGCTGCAGGAGATTGCGGCGG
ACGGGGAGTCGATTCCTATGCCGACTTCGGCATCCGCTCATCGCAGTAATCCGGACTTTGCCGACATGGGTTGGGGCATG
CTCGAGCTGGATATTTCGCCTTATCTCGGCAAGACCGAAAAGGTCAACGTGACGTTGCCTGGCTATGTAATTCAGCGCAT
CGATCGTTATGTGCGCGAACACAACGTCAAAAGCCGTTCCTCCTTTCTGGCGGATGCGGCGATGGAGAAACTGGTTCGTT
ACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CJ20 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | S1PPV5 |