Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 67541..67967 | Replicon | plasmid pS103EC_A |
| Accession | NZ_CP076694 | ||
| Organism | Escherichia coli strain S103EC | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | KQ261_RS25725 | Protein ID | WP_001372321.1 |
| Coordinates | 67541..67666 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 67743..67967 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KQ261_RS25695 (62652) | 62652..62879 | - | 228 | WP_001254388.1 | conjugal transfer relaxosome protein TraY | - |
| KQ261_RS25700 (62967) | 62967..63644 | - | 678 | WP_001348626.1 | PAS domain-containing protein | - |
| KQ261_RS25705 (63778) | 63778..64161 | - | 384 | WP_216684398.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| KQ261_RS25710 (64492) | 64492..65094 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| KQ261_RS25715 (65391) | 65391..66212 | - | 822 | WP_001234469.1 | DUF932 domain-containing protein | - |
| KQ261_RS25720 (66332) | 66332..66619 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| KQ261_RS26580 (66644) | 66644..66850 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| KQ261_RS26585 (66920) | 66920..67093 | + | 174 | Protein_82 | hypothetical protein | - |
| KQ261_RS26590 (67091) | 67091..67321 | - | 231 | WP_001426396.1 | hypothetical protein | - |
| KQ261_RS25725 (67541) | 67541..67666 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| KQ261_RS26595 (67608) | 67608..67757 | - | 150 | Protein_85 | plasmid maintenance protein Mok | - |
| - (67743) | 67743..67967 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (67743) | 67743..67967 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (67743) | 67743..67967 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (67743) | 67743..67967 | - | 225 | NuclAT_0 | - | Antitoxin |
| KQ261_RS25730 (67779) | 67779..67967 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| KQ261_RS25735 (67936) | 67936..68698 | - | 763 | Protein_87 | plasmid SOS inhibition protein A | - |
| KQ261_RS25740 (68695) | 68695..69129 | - | 435 | WP_000845940.1 | conjugation system SOS inhibitor PsiB | - |
| KQ261_RS25745 (69184) | 69184..71142 | - | 1959 | WP_086732397.1 | ParB/RepB/Spo0J family partition protein | - |
| KQ261_RS25750 (71208) | 71208..71441 | - | 234 | WP_000005990.1 | DUF905 family protein | - |
| KQ261_RS25755 (71504) | 71504..72043 | - | 540 | WP_000290841.1 | single-stranded DNA-binding protein | - |
| KQ261_RS25760 (72069) | 72069..72275 | - | 207 | WP_000275853.1 | hypothetical protein | - |
| KQ261_RS25765 (72188) | 72188..72523 | - | 336 | WP_014106969.1 | hypothetical protein | - |
| KQ261_RS26600 (72516) | 72516..72761 | - | 246 | WP_071533131.1 | hypothetical protein | - |
| KQ261_RS25770 (72686) | 72686..72886 | - | 201 | WP_025492130.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..146805 | 146805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T206300 WP_001372321.1 NZ_CP076694:c67666-67541 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T206300 NZ_CP102344:1377361-1377750 [Mycolicibacterium smegmatis]
ATGGTTATCGACACTTCTGCCCTCGTTGCCATCTTGACCGACGAACCCGACGCCGAGTTGTTGGAGGGGGCGGTGGCTGA
CGATCCTGTTCGGACTATGTCCACCGCGTCGTATCTGGAGACAGCGATCGTGATCGAAAGTCGCTTCGGCGAGCCAGGTG
GTCGCGAACTCGATCTGTGGTTGCATCGCGCATCAGTGGCACTGGTCGCTGTGGATGCCGATCAGGCCGACGCCGCCCGG
TTGGCTTACCGGAGATACGGCAAGGGGCGCCATCGTGCAGGCCTGAATTACGGCGACTGTTTTTCCTATGCGCTCGCCAA
GGTCAGCGGTCAGCCTTTGTTGTTCAAGGGCGAGGCTTTTCGGCTCACCGACGTCGCTGCGGTCCACTGA
ATGGTTATCGACACTTCTGCCCTCGTTGCCATCTTGACCGACGAACCCGACGCCGAGTTGTTGGAGGGGGCGGTGGCTGA
CGATCCTGTTCGGACTATGTCCACCGCGTCGTATCTGGAGACAGCGATCGTGATCGAAAGTCGCTTCGGCGAGCCAGGTG
GTCGCGAACTCGATCTGTGGTTGCATCGCGCATCAGTGGCACTGGTCGCTGTGGATGCCGATCAGGCCGACGCCGCCCGG
TTGGCTTACCGGAGATACGGCAAGGGGCGCCATCGTGCAGGCCTGAATTACGGCGACTGTTTTTCCTATGCGCTCGCCAA
GGTCAGCGGTCAGCCTTTGTTGTTCAAGGGCGAGGCTTTTCGGCTCACCGACGTCGCTGCGGTCCACTGA
Antitoxin
Download Length: 225 bp
>AT206300 NZ_CP076694:c67967-67743 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
