Detailed information of TA system TA206262

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 56536..56805
• Replicon: plasmid pS21EC_A
• Accession: NZ_CP076690
• Organism: Escherichia coli strain S21EC

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: KQ260_RS25245
• Protein ID: WP_001372321.1
• Coordinates: 56680..56805 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	56536..56601 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQ260_RS25210	51597..51845	+	249	WP_071606928.1	hypothetical protein	-
KQ260_RS25215	52329..52856	+	528	WP_000290793.1	single-stranded DNA-binding protein	-
KQ260_RS25220	52912..53145	+	234	WP_000006004.1	DUF905 domain-containing protein	-
KQ260_RS25225	53204..55162	+	1959	WP_216696440.1	ParB/RepB/Spo0J family partition protein	-
KQ260_RS25230	55217..55651	+	435	WP_000845901.1	conjugation system SOS inhibitor PsiB	-
KQ260_RS25235	55648..56410	+	763	Protein_68	plasmid SOS inhibition protein A	-
KQ260_RS25240	56379..56567	-	189	WP_001299721.1	hypothetical protein	-
-	56379..56603	+	225	NuclAT_0	-	-
-	56379..56603	+	225	NuclAT_0	-	-
-	56379..56603	+	225	NuclAT_0	-	-
-	56379..56603	+	225	NuclAT_0	-	-
-	56536..56601	-	66	-	-	Antitoxin
KQ260_RS25820	56589..56738	+	150	Protein_70	plasmid maintenance protein Mok	-
KQ260_RS25245	56680..56805	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
KQ260_RS25825	57266..57439	-	174	Protein_72	hypothetical protein	-
KQ260_RS25250	57737..58024	+	288	WP_000107537.1	hypothetical protein	-
KQ260_RS25255	58143..58964	+	822	WP_001234469.1	DUF932 domain-containing protein	-
KQ260_RS25260	59261..59908	-	648	WP_000614282.1	transglycosylase SLT domain-containing protein	-
KQ260_RS25265	60194..60577	+	384	WP_001151564.1	conjugal transfer relaxosome DNA-binding protein TraM	-
KQ260_RS25270	60771..61457	+	687	WP_000332487.1	PAS domain-containing protein	-
KQ260_RS25275	61551..61778	+	228	WP_001254388.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T206262 WP_001372321.1 NZ_CP076690:56680-56805 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T206262 NZ_CP102265:2250536-2250817 [Blautia obeum ATCC 29174]
ATGAAATATTCAATTAAACCAACCTCCAAATTCCAAAAAGATCTAAAACGTATCCAAAAAAGAGGTTATGATCTATCACT
TCTATCCGATGTCATCAAAAAGCTATCTAACGGTGAGTCCCTTCCACTAAAGTACCGAGATCATAACCTCATCGGTAACT
TTTGTGGATGTCGAGAATGTCATATTACTCCGGATTGGCTTCTCATCTACGAAATCTACGAAAAAGACCTTTATCTCTAT
CTAACCAGAACTGGTTCCCACAGTGATCTCTTCTCCAAATAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT206262 NZ_CP076690:c56601-56536 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin