Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
Location | 3611462..3612261 | Replicon | chromosome |
Accession | NZ_CP076689 | ||
Organism | Escherichia coli strain S21EC |
Toxin (Protein)
Gene name | yhaV | Uniprot ID | S1NYM6 |
Locus tag | KQ260_RS17855 | Protein ID | WP_000347251.1 |
Coordinates | 3611797..3612261 (+) | Length | 155 a.a. |
Antitoxin (Protein)
Gene name | prlF | Uniprot ID | S1PPV5 |
Locus tag | KQ260_RS17850 | Protein ID | WP_001296435.1 |
Coordinates | 3611462..3611797 (+) | Length | 112 a.a. |
Genomic Context
Location: 3609742..3611313 (1572 bp)
Type: Others
Protein ID: WP_001273763.1
Type: Others
Protein ID: WP_001273763.1
Location: 3611462..3611797 (336 bp)
Type: Antitoxin
Protein ID: WP_001296435.1
Type: Antitoxin
Protein ID: WP_001296435.1
Location: 3611797..3612261 (465 bp)
Type: Toxin
Protein ID: WP_000347251.1
Type: Toxin
Protein ID: WP_000347251.1
Location: 3613374..3614654 (1281 bp)
Type: Others
Protein ID: WP_000681950.1
Type: Others
Protein ID: WP_000681950.1
Location: 3614677..3615150 (474 bp)
Type: Others
Protein ID: WP_001295547.1
Type: Others
Protein ID: WP_001295547.1
Location: 3615161..3615940 (780 bp)
Type: Others
Protein ID: WP_000406214.1
Type: Others
Protein ID: WP_000406214.1
Location: 3615930..3616808 (879 bp)
Type: Others
Protein ID: WP_001295548.1
Type: Others
Protein ID: WP_001295548.1
Location: 3616826..3617260 (435 bp)
Type: Others
Protein ID: WP_000948824.1
Type: Others
Protein ID: WP_000948824.1
Location: 3607247..3608017 (771 bp)
Type: Others
Protein ID: WP_001058227.1
Type: Others
Protein ID: WP_001058227.1
Location: 3608033..3609367 (1335 bp)
Type: Others
Protein ID: WP_000599651.1
Type: Others
Protein ID: WP_000599651.1
Location: 3612316..3613125 (810 bp)
Type: Others
Protein ID: WP_000072187.1
Type: Others
Protein ID: WP_000072187.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KQ260_RS17835 (3607247) | 3607247..3608017 | - | 771 | WP_001058227.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
KQ260_RS17840 (3608033) | 3608033..3609367 | - | 1335 | WP_000599651.1 | galactarate/glucarate/glycerate transporter GarP | - |
KQ260_RS17845 (3609742) | 3609742..3611313 | + | 1572 | WP_001273763.1 | galactarate dehydratase | - |
KQ260_RS17850 (3611462) | 3611462..3611797 | + | 336 | WP_001296435.1 | type II toxin-antitoxin system antitoxin PrlF | Antitoxin |
KQ260_RS17855 (3611797) | 3611797..3612261 | + | 465 | WP_000347251.1 | type II toxin-antitoxin system ribonuclease toxin YhaV | Toxin |
KQ260_RS17860 (3612316) | 3612316..3613125 | - | 810 | WP_000072187.1 | aga operon transcriptional regulator AgaR | - |
KQ260_RS17865 (3613374) | 3613374..3614654 | + | 1281 | WP_000681950.1 | tagatose-bisphosphate aldolase subunit KbaZ | - |
KQ260_RS17870 (3614677) | 3614677..3615150 | + | 474 | WP_001295547.1 | PTS N-acetylgalactosamine transporter subunit IIB | - |
KQ260_RS17875 (3615161) | 3615161..3615940 | + | 780 | WP_000406214.1 | PTS N-acetylgalactosamine transporter subunit IIC | - |
KQ260_RS17880 (3615930) | 3615930..3616808 | + | 879 | WP_001295548.1 | PTS N-acetylgalactosamine transporter subunit IID | - |
KQ260_RS17885 (3616826) | 3616826..3617260 | + | 435 | WP_000948824.1 | PTS galactosamine/N-acetylgalactosamine transporter subunit IIA | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17777.14 Da Isoelectric Point: 9.4947
>T206256 WP_000347251.1 NZ_CP076689:3611797-3612261 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH
Download Length: 465 bp
>T206256 NZ_CP102247:c3157922-3157401 [Enterobacter asburiae]
GTGGCAAATCTCACGATCGAAATGTTATCTGAGGGAACCGATTACGACTTCGAGGATTTTGATTGTGGAGAACCCTCGCT
AAATGCCTTCCTTGCAGAACACCTGGTACGTCAGCACAATGGGCGTATTTTACGAGCCTACCTGCTTAAAGAGCGCGATC
GTCCGCGCGTCCTGGGTTATTACACGTTATCGGGAAGCTGCTTTGAAAGAGCGATGCTTCCTTCTAAGACGCAGCAGCGC
CGGATCCCTTATATCAACGTACCCAGCGTGACGCTGGGACGTCTGGCTGTAGATAAAACACTACAGGGAAACGAGTGGGG
CACAACGCTCGTTGCGCATGCTATGCGCGTTGTCTACCTGGCATCACAGGCTGTGGGGGTACACGGAATATTTGTTGATG
CCCTTAACGAGCAGGCCAAACAATTTTACCTGAAGCAGGGGTTTATCCCTCTGACAGGTGAAAACAGCCATTCTTTGTTC
TTCCCTACAAAATCTATCGAACGGCTGTTTGAGCAAGAGTGA
GTGGCAAATCTCACGATCGAAATGTTATCTGAGGGAACCGATTACGACTTCGAGGATTTTGATTGTGGAGAACCCTCGCT
AAATGCCTTCCTTGCAGAACACCTGGTACGTCAGCACAATGGGCGTATTTTACGAGCCTACCTGCTTAAAGAGCGCGATC
GTCCGCGCGTCCTGGGTTATTACACGTTATCGGGAAGCTGCTTTGAAAGAGCGATGCTTCCTTCTAAGACGCAGCAGCGC
CGGATCCCTTATATCAACGTACCCAGCGTGACGCTGGGACGTCTGGCTGTAGATAAAACACTACAGGGAAACGAGTGGGG
CACAACGCTCGTTGCGCATGCTATGCGCGTTGTCTACCTGGCATCACAGGCTGTGGGGGTACACGGAATATTTGTTGATG
CCCTTAACGAGCAGGCCAAACAATTTTACCTGAAGCAGGGGTTTATCCCTCTGACAGGTGAAAACAGCCATTCTTTGTTC
TTCCCTACAAAATCTATCGAACGGCTGTTTGAGCAAGAGTGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12321.92 Da Isoelectric Point: 4.5392
>AT206256 WP_001296435.1 NZ_CP076689:3611462-3611797 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE
Download Length: 336 bp
>AT206256 NZ_CP102247:c3158198-3157929 [Enterobacter asburiae]
ATGCCAGCACTTAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCGGCGAT
GACGAACCAGACCATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCAGAGGTCATTGAGCAGCACCGTCGAC
TCGTATTAAATGAAGCATCATGGAATGCGGTGATGGATGCCATTGACAATCCGCCTGAGCCAATCGAACGCTTGAAACGA
GCAGCAAAACGTCTTCGAAACATGGAGTGA
ATGCCAGCACTTAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCGGCGAT
GACGAACCAGACCATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCAGAGGTCATTGAGCAGCACCGTCGAC
TCGTATTAAATGAAGCATCATGGAATGCGGTGATGGATGCCATTGACAATCCGCCTGAGCCAATCGAACGCTTGAAACGA
GCAGCAAAACGTCTTCGAAACATGGAGTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CJ20 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | S1PPV5 |