Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3611462..3612261 Replicon chromosome
Accession NZ_CP076689
Organism Escherichia coli strain S21EC

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag KQ260_RS17855 Protein ID WP_000347251.1
Coordinates 3611797..3612261 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag KQ260_RS17850 Protein ID WP_001296435.1
Coordinates 3611462..3611797 (+) Length 112 a.a.

Genomic Context


KQ260_RS17845KQ260_RS17850KQ260_RS17855KQ260_RS17865KQ260_RS17870KQ260_RS17875KQ260_RS17880KQ260_RS17885KQ260_RS17835KQ260_RS17840KQ260_RS17860
Location: 3609742..3611313 (1572 bp)
Type: Others
Protein ID: WP_001273763.1
Location: 3611462..3611797 (336 bp)
Type: Antitoxin
Protein ID: WP_001296435.1
Location: 3611797..3612261 (465 bp)
Type: Toxin
Protein ID: WP_000347251.1
Location: 3613374..3614654 (1281 bp)
Type: Others
Protein ID: WP_000681950.1
Location: 3614677..3615150 (474 bp)
Type: Others
Protein ID: WP_001295547.1
Location: 3615161..3615940 (780 bp)
Type: Others
Protein ID: WP_000406214.1
Location: 3615930..3616808 (879 bp)
Type: Others
Protein ID: WP_001295548.1
Location: 3616826..3617260 (435 bp)
Type: Others
Protein ID: WP_000948824.1
Location: 3607247..3608017 (771 bp)
Type: Others
Protein ID: WP_001058227.1
Location: 3608033..3609367 (1335 bp)
Type: Others
Protein ID: WP_000599651.1
Location: 3612316..3613125 (810 bp)
Type: Others
Protein ID: WP_000072187.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KQ260_RS17835 (3607247)3607247..3608017-771WP_001058227.12-dehydro-3-deoxyglucarate aldolase-
KQ260_RS17840 (3608033)3608033..3609367-1335WP_000599651.1galactarate/glucarate/glycerate transporter GarP-
KQ260_RS17845 (3609742)3609742..3611313+1572WP_001273763.1galactarate dehydratase-
KQ260_RS17850 (3611462)3611462..3611797+336WP_001296435.1type II toxin-antitoxin system antitoxin PrlFAntitoxin
KQ260_RS17855 (3611797)3611797..3612261+465WP_000347251.1type II toxin-antitoxin system ribonuclease toxin YhaVToxin
KQ260_RS17860 (3612316)3612316..3613125-810WP_000072187.1aga operon transcriptional regulator AgaR-
KQ260_RS17865 (3613374)3613374..3614654+1281WP_000681950.1tagatose-bisphosphate aldolase subunit KbaZ-
KQ260_RS17870 (3614677)3614677..3615150+474WP_001295547.1PTS N-acetylgalactosamine transporter subunit IIB-
KQ260_RS17875 (3615161)3615161..3615940+780WP_000406214.1PTS N-acetylgalactosamine transporter subunit IIC-
KQ260_RS17880 (3615930)3615930..3616808+879WP_001295548.1PTS N-acetylgalactosamine transporter subunit IID-
KQ260_RS17885 (3616826)3616826..3617260+435WP_000948824.1PTS galactosamine/N-acetylgalactosamine transporter subunit IIA-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T206256 WP_000347251.1 NZ_CP076689:3611797-3612261 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T206256 NZ_CP102247:c3157922-3157401 [Enterobacter asburiae]
GTGGCAAATCTCACGATCGAAATGTTATCTGAGGGAACCGATTACGACTTCGAGGATTTTGATTGTGGAGAACCCTCGCT
AAATGCCTTCCTTGCAGAACACCTGGTACGTCAGCACAATGGGCGTATTTTACGAGCCTACCTGCTTAAAGAGCGCGATC
GTCCGCGCGTCCTGGGTTATTACACGTTATCGGGAAGCTGCTTTGAAAGAGCGATGCTTCCTTCTAAGACGCAGCAGCGC
CGGATCCCTTATATCAACGTACCCAGCGTGACGCTGGGACGTCTGGCTGTAGATAAAACACTACAGGGAAACGAGTGGGG
CACAACGCTCGTTGCGCATGCTATGCGCGTTGTCTACCTGGCATCACAGGCTGTGGGGGTACACGGAATATTTGTTGATG
CCCTTAACGAGCAGGCCAAACAATTTTACCTGAAGCAGGGGTTTATCCCTCTGACAGGTGAAAACAGCCATTCTTTGTTC
TTCCCTACAAAATCTATCGAACGGCTGTTTGAGCAAGAGTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT206256 WP_001296435.1 NZ_CP076689:3611462-3611797 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT206256 NZ_CP102247:c3158198-3157929 [Enterobacter asburiae]
ATGCCAGCACTTAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCGGCGAT
GACGAACCAGACCATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCAGAGGTCATTGAGCAGCACCGTCGAC
TCGTATTAAATGAAGCATCATGGAATGCGGTGATGGATGCCATTGACAATCCGCCTGAGCCAATCGAACGCTTGAAACGA
GCAGCAAAACGTCTTCGAAACATGGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A829CJ20


Antitoxin

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Source
ID
Structure
AlphaFold DBS1PPV5

References