Detailed information of TA system TA020624

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1149128..1149754
• Replicon: chromosome
• Accession: NC_002967
• Organism: Treponema denticola ATCC 35405

Toxin (Protein)

• Gene name: higB
• Uniprot ID: Q73NN6
• Locus tag: TDE_RS05340
• Protein ID: WP_002677634.1
• Coordinates: 1149446..1149754 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: TDE_RS05335
• Protein ID: WP_002670672.1
• Coordinates: 1149128..1149436 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TDE_RS05310	1144412..1145731	+	1320	WP_002682414.1	leucine-rich repeat domain-containing protein	-
TDE_RS05315	1145770..1146999	+	1230	WP_002670666.1	dicarboxylate/amino acid:cation symporter	-
TDE_RS05320	1147058..1147687	+	630	WP_002670667.1	adenylate kinase	-
TDE_RS05325	1147819..1148340	-	522	WP_002670668.1	SRPBCC family protein	-
TDE_RS05330	1148324..1148995	-	672	WP_002670670.1	TetR/AcrR family transcriptional regulator	-
TDE_RS05335	1149128..1149436	-	309	WP_002670672.1	helix-turn-helix domain-containing protein	Antitoxin
TDE_RS05340	1149446..1149754	-	309	WP_002677634.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
TDE_RS05345	1149782..1149931	+	150	WP_010956878.1	hypothetical protein	-
TDE_RS05350	1149972..1151351	-	1380	WP_002682416.1	tyrosine phenol-lyase	-
TDE_RS05355	1151467..1152087	+	621	WP_002671735.1	hypothetical protein	-
TDE_RS05360	1152068..1152889	+	822	WP_002682418.1	hypothetical protein	-
TDE_RS05365	1152904..1153446	-	543	WP_002670683.1	ATP-binding protein	-
TDE_RS05370	1153463..1153801	-	339	WP_002670686.1	anti-sigma factor antagonist	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-86)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11736.96 Da
• Isoelectric Point: 10.6864

>T20624 WP_002677634.1 NC_002967:c1149754-1149446 [Treponema denticola ATCC 35405]
MRIIETPVFTKQINRLLDEDTYKQFKEYLVCNPLKGKLIKGGGGIRKIRWSKKNTGKSGGIRIIYFIKTETKIYLLFAYS
KSDAESITKKQINMLASFIKGL

Nucleotide

• Length: 309 bp

>T20624 NC_002967:c1149754-1149446 [Treponema denticola ATCC 35405]
ATGCGAATTATAGAAACGCCTGTTTTTACAAAACAAATAAATAGGCTACTGGACGAAGATACATATAAACAATTTAAAGA
ATATCTAGTATGTAATCCATTGAAAGGTAAATTGATTAAGGGTGGCGGCGGAATACGAAAAATAAGATGGAGCAAAAAGA
ATACCGGAAAAAGCGGCGGTATTAGGATTATTTATTTTATAAAAACTGAAACAAAGATATATTTGTTGTTTGCTTATTCA
AAAAGTGATGCAGAGAGCATTACAAAAAAACAAATAAATATGTTGGCAAGTTTTATTAAAGGTTTATAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11533.43 Da
• Isoelectric Point: 9.6884

>AT20624 WP_002670672.1 NC_002967:c1149436-1149128 [Treponema denticola ATCC 35405]
MFKRKKMSDEMFAELLQSVKEAVLIEKGEIPPARVFEIEPLDIAKIRSKTNKTQEEFASMLNISIGTLRNWEQGRRKPDG
AALSLLKIVSANPQYVESVLQG

Nucleotide

• Length: 309 bp

>AT20624 NC_002967:c1149436-1149128 [Treponema denticola ATCC 35405]
ATGTTTAAAAGAAAAAAAATGAGTGATGAGATGTTTGCCGAATTACTCCAAAGCGTAAAGGAAGCTGTTTTAATTGAAAA
AGGAGAAATTCCTCCCGCCAGAGTTTTTGAAATAGAGCCTTTGGATATTGCCAAAATACGCAGTAAGACAAATAAAACAC
AAGAAGAATTTGCATCTATGCTTAATATCAGTATCGGTACCTTACGAAACTGGGAACAAGGCAGGCGTAAGCCTGATGGG
GCGGCCTTGTCTCTACTTAAAATCGTTTCGGCTAATCCTCAATATGTAGAAAGCGTGCTGCAGGGATAA

Structures

Toxin

• AlphaFold DB: Q73NN6